Immunologic Research

, Volume 66, Issue 6, pp 723–725 | Cite as

Suspected adverse effects after human papillomavirus vaccination: a temporal relationship

  • Shu-ichi IkedaEmail author
  • Akiyo Hineno
  • Kazuki Ozawa
  • Tomomi Kinoshita


In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalities in laboratory test results. Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Our study has shown that the period of HPV vaccination considerably overlapped with that of unique postvaccination symptom development, adding that new patients with possible HPV vaccine-related symptoms have not appeared during our recent 28-month follow-up period. This social episode has now subsided in Japan.


Human papillomavirus vaccination Adverse effects Peripheral sympathetic nerve dysfunction Chronic regional pain syndrome Cognitive dysfunction 



This study was supported by a grant from a Health and Labour Science Research Grant on Emerging and Re-emerging Infectious Diseases (Establishment of Treatments and Providing Information on Symptoms after HPV vaccination, H28-001) to S.I. from the Ministry of Public Heath, Labour and Welfare, Japan.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Shu-ichi Ikeda
    • 1
    Email author
  • Akiyo Hineno
    • 1
    • 2
  • Kazuki Ozawa
    • 2
  • Tomomi Kinoshita
    • 2
  1. 1.Intractable Disease Care CenterShinshu University HospitalMatsumotoJapan
  2. 2.Department of Medicine (Neurology and Rheumatology)Shinshu University School of MedicineMatsumotoJapan

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