Autonomic dysfunction and HPV immunization: an overview
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This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. It is known that autoimmunity and autoantibodies are present in a subset of patients with CRPS, POTS, SFN, ME/CFS, and fibromyalgia. This article proposes that vaccine-triggered, immune-mediated autonomic dysfunction could lead to the development of de novo post-HPV vaccination syndrome possibly in genetically susceptible individuals. Being cognizant that a temporal relationship between vaccination and symptom onset does not necessarily equate to causality, mounting evidence of case series calls for well-designed case-control studies to determine the prevalence and possible causation between these symptom clusters and HPV vaccines. Since personalized medicine is gaining momentum, the use of adversomics and pharmacogenetics may eventually help identify individuals who are predisposed to HPV vaccine adverse events.
KeywordsHPV vaccine Autonomic dysfunction Autoimmunity Postural orthostatic tachycardia syndrome Chronic regional pain syndrome Small fiber neuropathy Fibromyalgia Myalgic encephalomyelitis Chronic fatigue syndrome
All authors actively participated in the design and writing of the article. All authors approved the final version of the manuscript.
Compliance with ethical standards
Conflicts of interest
Manuel Martínez-Lavín declares no conflict of interest. Jeanne Hendrickson declares no conflict of interest. Svetlana Blitshteyn has served as a medical expert witness on cases of POTS and other neurologic syndromes after Gardasil vaccine. Louise Brinth declares no conflict of interest.
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