Endocrine Pathology

, Volume 30, Issue 3, pp 219–236 | Cite as

Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature

  • Giulia Cossu
  • Jean-Philippe Brouland
  • Stefano La Rosa
  • Chiara Camponovo
  • Edoardo Viaroli
  • Roy Thomas Daniel
  • Mahmoud MessererEmail author


The 2017 World Health Organization classification of central nervous system and endocrine tumors have introduced significant changes in the diagnostic criteria for pituitary lesions. The aim of our paper is to describe the epidemiological, clinico-pathological, and radiological features of a single consecutive institutional surgical series of rare pituitary lesions, using these new criteria. Of the 316 endoscopic endonasal trans-sphenoidal approaches performed for pituitary lesions between 2010 and 2018, 15 rare lesions were encountered. These included metastases, pituitary carcinomas, pituicytomas, granular cell tumor, primary pituitary lymphomas, germinoma, mixed gangliocytoma–adenoma, hypophysitis, and pituitary hyperplasia. Their clinical, radiological, and pathological features are herewith presented along with a literature review that enabled us to propose an algorithm to facilitate a diagnosis for rare pituitary lesions.


Pituitary lesion Rare disease Surgery Pathology Radiology 


Compliance with Ethical Standards

Conflict of Interest



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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Giulia Cossu
    • 1
  • Jean-Philippe Brouland
    • 2
    • 3
  • Stefano La Rosa
    • 2
    • 3
  • Chiara Camponovo
    • 4
  • Edoardo Viaroli
    • 1
  • Roy Thomas Daniel
    • 1
    • 3
  • Mahmoud Messerer
    • 1
    • 3
    Email author
  1. 1.Department of NeurosurgeryLausanne University HospitalLausanneSwitzerland
  2. 2.Department of Clinical Pathology, Institute of PathologyLausanne University HospitalLausanneSwitzerland
  3. 3.University of LausanneLausanneSwitzerland
  4. 4.Department of EndocrinologyUniversity Hospital of LausanneLausanneSwitzerland

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