Adrenal Teratoma: a Case Series and Review of the Literature
- 205 Downloads
Adrenal teratomas are rare neoplasms and there is limited data on their surgical outcomes and long-term prognosis. We aimed to review our institutional experience and compare this to the existing literature on adrenal teratomas in adults and children. An institutional pathology database was searched for cases of adrenal teratoma (June 1956–July 2016). Clinical and imaging data were abstracted from the medical records and pathology slides were obtained for review. In addition, a PubMed search for “adrenal teratoma” from June 1952 to July 2016 was performed to identify reports of primary adrenal teratoma in patients of all ages. Of 7706 patients who underwent adrenalectomy during the study period at our institution, three patients were identified with adrenal teratoma. Patients were 24, 26, and 29 years of age, respectively. Two patients presented with abdominal pain and two of the three underwent a laparoscopic adrenalectomy. A pathologic examination revealed mature cystic teratomas that frequently displayed well-differentiated respiratory, digestive, and squamous epithelia. Eighteen case reports in the literature were identified in patients 17–61 years of age. Patients presented most frequently with abdominal or flank pain (63.6%). Median tumor diameter was 9.0 cm and tumors were frequently left-sided (81.8%), cystic (63.6%), and calcified (72.7%) on either radiologic or pathologic examination. Primary adrenal teratomas are rare neoplasms that typically present as large, left-sided nodules with cystic and calcified components seen radiographically. Although the data are limited, they are generally amenable to laparoscopic resection and have a very favorable prognosis.
KeywordsTeratoma Adrenal Retroperitoneal Adrenalectomy
This publication was supported in part by the H H Lee Research Program.
Compliance with Ethical Standards
Statement of Human Rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Bhatti A, Al-Hindi H, Azzam A, Amin T, Abu-Zaid A (2013) Mature (benign) cystic retroperitoneal teratoma involving the left adrenal gland in a 22-year-old male: a case report and literature review. Case reports in oncological medicine 2013:610280. doi: 10.1155/2013/610280 CrossRefPubMedPubMedCentralGoogle Scholar
- 2.Castillo OA, Vitagliano G, Villeta M, Arellano L, Santis O (2006) Laparoscopic resection of adrenal teratoma. JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons 10 (4):522–524Google Scholar
- 10.Li H, Zhao T, Wei Q, Yuan H, Cao D, Shen P, Liu L, Zeng H, Chen N (2015) Laparoscopic resection of a huge mature cystic teratoma of the right adrenal gland through retroperitoneal approach: a case report and literature review. World J Surg Oncol 13:318. doi: 10.1186/s12957-015-0734-z CrossRefPubMedPubMedCentralGoogle Scholar
- 17.Powell G, Burrows C, Houghton A, Otter M (2012) An incidental peri-adrenal cystic lesion. BMJ case reports 2012. doi: 10.1136/bcr-2012-006606
- 22.Mostert MC, Verkerk AJ, van de Pol M, Heighway J, Marynen P, Rosenberg C, van Kessel AG, van Echten J, de Jong B, Oosterhuis JW, Looijenga LH (1998) Identification of the critical region of 12p over-representation in testicular germ cell tumors of adolescents and adults. Oncogene 16 (20):2617–2627. doi: 10.1038/sj.onc.1201787 CrossRefPubMedGoogle Scholar