Endocrine Pathology

, Volume 28, Issue 2, pp 139–145 | Cite as

Sarcomatoid Adrenal Carcinoma: Case Report with Contribution to Pathogenesis

  • Wolfgang SaegerEmail author
  • Werner Mohren
  • Matthias Behrend
  • Peter Iglauer
  • Waldemar Wilczak


A tumor in the adrenal region with two metastases in the liver was classified as poorly differentiated sarcoma on the base of extensive immunostainings (expression of vimentin, desmin, myogenin, and CD31, no expression of inhibin, melan A). Four years later in a second examination with molecular methods for a study of adrenal sarcomas, this diagnosis must be revised due to the lack of MDM-2 gene amplification and FKHR translocation which exclude sarcoma. Further immunostainings of many other parts of the tumor showed in one area more mature tumor tissue expressing synaptophysin, SF-1, and melan A. From these findings we classified an adrenal cortical cancer with predominant dedifferentiation into a sarcomatoid adrenal carcinoma. The properties of this very rare cancer type are presented and discussed.


Adrenal carcinoma Sarcomatoid carcinoma Sarcoma Molecular pathology Immunostaining 


Compliance with Ethical Standards

Conflict of Interests

The authors declare that they have no conflict of interests.


Due to the subtitle (case report) of the manuscript, an approval on ethics appears to be not necessary.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Wolfgang Saeger
    • 1
    Email author
  • Werner Mohren
    • 2
  • Matthias Behrend
    • 3
  • Peter Iglauer
    • 4
  • Waldemar Wilczak
    • 4
  1. 1.Institute of Pathology and Neuropathology of the University of HamburgHamburgGermany
  2. 2.Institute of PathologyHospital DeggendorfDeggendorfGermany
  3. 3.Clinic for SurgeryHospital DeggendorfDeggendorfGermany
  4. 4.Institute of Pathology of the University of HamburgHamburgGermany

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