, Volume 17, Issue 4, pp 475–478 | Cite as

Response to “Fallacies of Mice Experiments”

  • Zhenyu Gao
  • Alyse M. Thomas
  • Michael N. Economo
  • Amada M. Abrego
  • Karel Svoboda
  • Chris I. De Zeeuw
  • Nuo LiEmail author


In a recent Editorial, De Schutter commented on our recent study on the roles of a cortico-cerebellar loop in motor planning in mice (De Schutter 2019, Neuroinformatics, 17, 181–183, Gao et al. 2018, Nature, 563, 113–116). Two issues were raised. First, De Schutter questions the involvement of the fastigial nucleus in motor planning, rather than the dentate nucleus, given previous anatomical studies in non-human primates. Second, De Schutter suggests that our study design did not delineate different components of the behavior and the fastigial nucleus might play roles in sensory discrimination rather than motor planning. These comments are based on anatomical studies in other species and homology-based arguments and ignore key anatomical data and neurophysiological experiments from our study. Here we outline our interpretation of existing data and point out gaps in knowledge where future studies are needed.


Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeuroscienceErasmus MCRotterdamthe Netherlands
  2. 2.Department of NeuroscienceBaylor College of MedicineHoustonUSA
  3. 3.Janelia Research CampusAshburnUSA
  4. 4.Department of Biomedical EngineeringBoston UniversityBostonUSA
  5. 5.Netherlands Institute for NeuroscienceAmsterdamthe Netherlands

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