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Exploring the molecular insights of concurrent composite mucoepidermoid carcinoma and papillary thyroid carcinoma

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mucoepidermoid carcinoma


papillary thyroid cancer


sclerosing mucoepidermoid carcinoma with eosinophilia


fine needle aspiration


follicular variant


variant of unknown significance


  1. 1.

    Z.W. Baloch, A.C. Solomon, V.A. LiVolsi, Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod. Pathol. 13, 802 (2000)

  2. 2.

    Z.W. Baloch, V.A. LiVolsi, Special types of thyroid carcinoma. Histopathology 72, 40 (2018)

  3. 3.

    J.L. Hunt, Unusual thyroid tumors: a review of pathologic and molecular diagnosis. Expert Rev. Mol. Diagn. 5, 725 (2005)

  4. 4.

    R.C. Niessen, R.H. Sijmons, J. Ou, S.G.M. Olthof, J. Osinga, M.J. Ligtenberg, F.B.L. Hogervorst, M.M. Weiss, C.M.J. Tops, F.J. Hes, G.H. de Bock, C.H.C.M. Buys, J.H. Kleibeuker, R.M.W. Hofstra, MUTYH and the mismatch repair system: partners in crime? Hum. Genet. 119, 206 (2006)

  5. 5.

    M. Sponziello, G. Silvestri, A. Verrienti, A. Perna, F. Rosignolo, C. Brunelli, V. Pecce, E.D. Rossi, C.P. Lombardi, C. Durante, S. Filetti, G.Fadda, A novel nonsense EIF1AX mutation identified in a thyroid nodule histologically diagnosed as oncocytic carcinoma. Endocrine 62, 492 (2018).

  6. 6.

    N.S. Jayakody, M. Faoury, L.R. Fraser, S. Jogai, N.N. Patel, Composite poorly differentiated mucoepidermoid carcinoma of the thyroid and follicular variant of papillary thyroid carcinoma. Report of a case and review of the literature. J. Surg. Case Rep. 2019, rjz092 (2019)

  7. 7.

    F. Fulciniti, E. Vuttariello, C. Calise, M. Monaco, L. Pezzullo, M.G. Chiofalo, F. Di Gennaro, M.G. Malzone, A.C. Campanile, N.S. Losito, G. Botti, G. Chiappetta, Combined papillary and mucoepidermoid carcinoma of the thyroid gland: a possible collision tumor diagnosed on fine-needle cytology. Report of a case with immunocytochemical and molecular correlations. Endocr. Pathol. 26, 140 (2015)

  8. 8.

    Y.H. Jung, M.S. Kang, Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report. Korean Med. Sci. 25, 1683 (2010)

  9. 9.

    V. Nath, G.E. Parks, M. Baliga, E.O. Hartle, K.R. Geisinger, V. Shenoy, Mucoepidermoid carcinoma of the thyroid with concomitant papillary carcinoma: comparison of findings on fine-needle aspiration biopsy and histology. Endocr. Pathol. 25, 427 (2014)

  10. 10.

    S. Taconet, J. Bosq, D. Hartl, M. Schlumberger, S. Leboulleux, J.-Y. Scoazec, A. Al-Ghuzlan, Composite mucoepidermoid carcinoma and columnar cell variant of papillary carcinoma of the thyroid: a case report and review of the literature. Int. J. Surg. Pathol. 24, 336 (2016)

  11. 11.

    M. Kantor, J. Sobrado, S. Patel, S. Eiseler, C. Ochner, Hereditary colorectal tumors: a literature review on MUTYH-associated polyposis. Gastroenterol. Res. Pract. 2017, 8693182 (2017). https://doi.org/10.1155/2017/8693182

  12. 12.

    K.A. Ashton, A. Proietto, G. Otton, I. Symonds, R.J. Scott, Genetic variants in MUTYH are not associated with endometrial cancer risk. Hered. Cancer Clin. Pract. 7(1), 3 (2009). https://doi.org/10.1186/1897-4287-7-3

  13. 13.

    M. Matsuda, K. Miyagawa, M. Takahashi, T. Fukuda, T. Kataoka, T. Asahara, H. Inui, M. Watatani, M. Yasutomi, N. Kamada, K. Dohi, K. Kamiya, Mutations in the RAD54 recombination gene in primary cancers. Oncogene 18, 3427 (1999)

  14. 14.

    A.A. Riccio, G. Cingolani, eJ.M. Pascal, PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res. 44, 1691 (2016)

  15. 15.

    I.A. Adzhubei, S. Schmidt, L. Peshkin, V.E. Ramensky, A. Gerasimova, P. Bork, A.S. Kondrashov, S.R. Sunyaev, A method and server for predicting damaging missense mutations. Nat. Methods 7, 248 (2010).

  16. 16.

    A. Astolfi, M. Fiore, F. Melchionda, V. Indio, S.N. Bertuccio, A. Pession, BCOR involvement in cancer. Epigenomics 11, 835 (2019)

  17. 17.

    M.A.M. Ali, H. Strickfaden, B.L. Lee, L. Spyracopoulos, M.J. Hendzel, RYBP is a K63-ubiquitin-chain-binding protein that inhibits homologous recombination repair. Cell Rep. 22, 383 (2018)

  18. 18.

    R.R. Broaddus, P.M. Lynch, K.H. Lu, R. Luthra, S.J. Michelson, Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome. Mod. Pathol. 17, 981 (2004)

  19. 19.

    A.L. Feng, A. Le, D.N. Johnson, M.A. Varvares, Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review. Laryngoscope 128, 2759 (2018)

  20. 20.

    R.P. Stulp, J.C. Herkert, A. Karrenbeld, B. Mol, Y.J. Vos, R.H. Sijmons, Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum. Hered. Cancer Clin. Pr. 6, 15 (2008)

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The study was supported by Ministero dell’Istruzione, dell’Università e della Ricerca, Italy (MIUR, investigator grant 2015 project code PRIN 2015HPMLFY to CD).

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Correspondence to Sponziello Marialuisa.

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All procedures involving humans were in accordance with the ethical standards of the institutional research committee (Ethics Committee of Azienda Universitaria Policlinico Umberto I, Rome, Italy; Prot. 806/16, Rif. 4233) and with the 1964 Helsinki declaration and its later amendments.

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Rosa, F., Marialuisa, S., Raffella, C. et al. Exploring the molecular insights of concurrent composite mucoepidermoid carcinoma and papillary thyroid carcinoma. Endocrine (2020). https://doi.org/10.1007/s12020-020-02221-8

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