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Thermal ablation procedures: the need of careful appraisal

  • Claudio Maurizio PacellaEmail author
  • Enrico Papini
Letter to the Editor

To the Editor:

We read with attention the paper entitled “Efficacy of thermal ablation in benign nonfunctioning solid thyroid nodule: A systematic review and meta-analysis” written by Trimboli PP et al. and we found it rather well written and interesting. However, we disagree with some methodological aspects and part of the considerations reported in the paper and we assume that a few precisations are strongly deserved.

The authors claim that the study was addressed at obtaining a robust evidence on the effectiveness of thermal therapies in reducing the volume of benign thyroid nodules. The meta-analysis mainly results, however, in a comparison between the two most tested ablation techniques, laser (LA) and radiofrequency (RFA). A few of the conclusions that arise from the results presented in the paper seem questionable and need a clarification to prevent potentially misleading messages for clinical practice.

First of all, how do the authors explain the 12-month volume reduction...


Compliance with ethical standards

Conflict of interest

C.M.P. is consultant for ELESTA SrL, Calenzano (Florence), Italy. E.P. declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.


  1. 1.
    G. Mauri, L. Cova, C. G. Monaco, L. M. Sconfienza, S. Corbetta, et al. Benign thyroid nodules treatment using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA). Int. J. Hyperth. 33, 295–299 (2017).CrossRefGoogle Scholar
  2. 2.
    A. Ben Hamou, E. Ghanassia, S. Espiard, H. Abi Rached, A. Jannin et al. Safety and efficacy of thermal ablation (radiofrequency and laser): should we treat all types of thyroid nodules? (dagger). Int J. Hyperth. 36, 666–676 (2019).CrossRefGoogle Scholar
  3. 3.
    W.F. Sui, J.Y. Li, J.H. Fu, Percutaneous laser ablation for benign thyroid nodules: a meta-analysis. Oncotarget 8, 83225–83236 (2017).PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Diagnostic Imaging and Interventional RadiologyRegina Apostolorum HospitalAlbano LazialeItaly
  2. 2.Deparment of Endocrinology and MetabolismRegina Apostolrum HospitalAlbano LazialeItaly

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