, Volume 66, Issue 2, pp 301–309 | Cite as

Physical exercise improves functional capacity and quality of life in patients with acromegaly: a 12-week follow-up study

  • Tatiana Rafaela Lemos Lima
  • Leandro Kasuki
  • Monica Gadelha
  • Agnaldo José LopesEmail author
Original Article



Although the focus of acromegaly treatment is the hormonal control of the disease, a new perspective must be given to the functional rehabilitation of these patients, especially when considering the recent increase in survival. The aim of this study was to evaluate the effects of therapist-oriented home rehabilitation (TOHR) on patients with acromegaly.

Patients and methods

Seventeen adults with acromegaly followed an exercise programme from a booklet with instructions for each exercise prescribed, for 2 months, and were reassessed after 1 month of washout. At each of the 3 timepoints (before and after the intervention and at the 1-month follow-up), the participants were subjected to the following assessments: body composition through bioimpedance, health-related quality of life (HRQoL) using the Acromegaly Quality of Life (AcroQoL) questionnaire, general fatigue through the Functional Assessment of Chronic Illness Therapy-Fatigue scale, handgrip strength, lower extremity functionality using isometric dynamometry and the Lower Extremity Functional Scale (LEFS), body balance through stabilometry, and functional capacity through 6-minute walking distance (6MWD).


After performing TOHR, improvements in general fatigue, quadriceps muscle strength, LEFS, 6MWD, balance control and all AcroQoL dimensions were observed (all P < 0.05). After 1 month of washout, however, these gains were lost for all parameters, except the LEFS and balance control.


In acromegaly, TOHR results in improvements in muscle function, functional capacity, general fatigue, body balance, and HRQoL. Large randomized controlled trials are needed to replicate these benefits and to recommend rehabilitation, especially for those with long-term illness.


Acromegaly Muscles Rehabilitation Exercise Quality of life 



The authors thank the participants for their continuing participation in this research effort.


This study was funded by the Conselho Brasileiro de Desenvolvimento Científico e Tecnológico (grant number 304625/2016-7), the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (grant number E-26/202.679/2018), and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance Code 001).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in this study.

Supplementary material

12020_2019_2011_MOESM1_ESM.pdf (906 kb)
Supplementary Information


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Rehabilitation Sciences Post-graduate ProgrammeAugusto Motta University Centre (UNISUAM)Rio de JaneiroBrazil
  2. 2.Neuroendocrinology Research Centre/Endocrinology Section, Medical School and Clementino Fraga Filho University HospitalFederal University of the Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  3. 3.Neuroendocrine Unit, Paulo Niemeyer State Brain InstituteSecretary of State for Health of Rio de JaneiroRio de JaneiroBrazil
  4. 4.Post-graduate Programme in Medical Sciences, School of Medical SciencesState University of the Rio de Janeiro (UERJ)Rio de JaneiroBrazil

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