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Endocrine

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Trabecular bone score: a useful clinical tool for the evaluation of skeletal health in women of short stature

  • Pedro Paulo Martins Alvarenga
  • Barbara Campolina SilvaEmail author
  • Mariana Picoli Diniz
  • Milena Bellei Leite
  • Caroline Alves Moreira da Silva
  • Jessica de Cássia Mendes Eleutério
  • Maria Marta Sarquis Soares
  • John P. Bilezikian
  • Bruno Muzzi Camargos
Original Article
  • 15 Downloads

Abstract

Purpose

Areal bone mineral density (aBMD) by DXA is underestimated in those with smaller bones and overestimated in those with larger bones. Trabecular bone score (TBS) predicts fracture risk, and is not influenced by bone size. The aim of this study was to evaluate TBS and BMD in women with short stature.

Methods

We retrospectively analyzed DXA scans of all women aged 50–90 years with short stature (<144 cm) obtained in a single center, from 2006 to 2016. The comparison group comprised women >161 cm in height, matched for age and LS BMD, selected from the same database.

Results

The study population included 342 women. The two groups were similar in age, and aBMD at the LS and total hip. Femoral neck aBMD was lower in cases than in taller women. In contrast, TBS was higher in women with short stature than in their taller counterparts (1.347 ± 0.102 vs. 1.250 ± 0.110; p < 0.001). Bone mineral apparent density (BMAD) and the LS TBS-adjusted BMD T-score were also significantly higher in shorter than in taller women. From the entire cohort, 121 women (67 cases) were osteoporotic by aBMD determinations. Among these subjects, TBS was also greater in cases (1.303 ± 0.103) than in women with standard height (1.190 ± 0.099; p < 0.001). Despite being considered osteoporotic, 36% of short women, but none of the taller ones, had a normal TBS.

Conclusions

TBS can be a useful adjunct to aBMD for assessing bone quality in short women, in whom aBMD measurement tends to read lower, and, thus could overestimate fracture risk.

Keywords

Trabecular bone score DXA Short stature Fracture risk Osteoporosis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Statement

This work was partially supported by the Foundation for Research Support of the State of Minas Gerais—FAPEMIG (to PPMA and MMSS). This study consisted of review of medical records, and involved no more than minimal risks to subjects. The Institutional Review Board approved the protocol. All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Pedro Paulo Martins Alvarenga
    • 1
    • 2
  • Barbara Campolina Silva
    • 1
    • 3
    • 4
    Email author
  • Mariana Picoli Diniz
    • 1
  • Milena Bellei Leite
    • 1
  • Caroline Alves Moreira da Silva
    • 1
  • Jessica de Cássia Mendes Eleutério
    • 1
  • Maria Marta Sarquis Soares
    • 2
    • 3
  • John P. Bilezikian
    • 5
  • Bruno Muzzi Camargos
    • 6
  1. 1.School of MedicineCentro Universitário de Belo Horizonte – UNI-BHBelo HorizonteBrazil
  2. 2.Department of MedicineFederal University of Minas Gerais – UFMG –Belo HorizonteBrazil
  3. 3.Division of Endocrinology, Hospital Felicio RochoBelo HorizonteBrazil
  4. 4.Division of Endocrinology, Santa Casa de Belo HorizonteBelo HorizonteBrazil
  5. 5.Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  6. 6.Centro de Densitometria Óssea/Hospital Mater DeiBelo HorizonteBrazil

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