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Endocrine

, Volume 65, Issue 3, pp 714–716 | Cite as

Human heart shifts from IGF-1 production to utilization with chronic heart failure

  • Roberta D’Assante
  • Raffaele Napoli
  • Andrea Salzano
  • Carlotta Pozza
  • Alberto Maria Marra
  • Michele Arcopinto
  • Giuseppe Perruolo
  • Salvatore Milano
  • Pietro Formisano
  • Lavinia Saldamarco
  • Plinio Cirillo
  • Antonio CittadiniEmail author
Research Letter

Chronic heart failure (CHF) is characterized by multiple hormonal and metabolic deficiencies (MHD) [1, 2]. In this context, abnormalities of growth hormone (GH) and its effector insulin like growth factor-1 (IGF-1) play a distinct and relevant role [3, 4]. Circulating levels of IGF-1 have been associated with cardiovascular events and mortality in CHF, but the benefit of the use of IGF-1 as prognostic marker in CHF is still unresolved [5]. Stimulation of IGF-1 receptors by the hormone can occur in response to the plasma circulating IGF-1 or to the local paracrine/autocrine production. Cardiomyocytes are able to produce IGF-1 mRNA and experimental conditions of heart hypertrophy are associated with an increase in such production, suggesting that modulation in local IGF-1 production might be an adaptive response to the need of local growth [6]. However, no data are available on the handling of IGF-1 by the human heart in vivo in healthy subjects or in patients with CHF. Thus, aim of the...

Notes

Acknowledgements

A. Salzano received research grant support from Cardiopath, UniNA and Compagnia di San Paolo, as part of the Programme STAR. AM. Marra was supported by an institutional grant from Italian Healthcare Ministry (Ricerca Finalizzata for young researchers). (Project n. GR-2016-02364727).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

The study protocol was conducted according to the Declaration of Helsinki and was approved by the Federico II University Ethics Committee.

Informed consent

Informed consent was obtained from all subjects included in the study.

References

  1. 1.
    M. Arcopinto, A. Salzano, E. Bossone, F. Ferrara, E. Bobbio, D. Sirico, O. Vriz, C. De Vincentiis, M. Matarazzo, L. Saldamarco, F. Sacca, R. Napoli, M. Lacoviello, V. Triggiani, A.M. Isidori, C. Vigorito, J. Isgaard, A. Cittadini, Multiple hormone deficiencies in chronic heart failure. Int. J. Cardiol. 184, 421–423 (2015).  https://doi.org/10.1016/j.ijcard.2015.02.055 CrossRefGoogle Scholar
  2. 2.
    A. Salzano, A.M. Marra, F. Ferrara, M. Arcopinto, E. Bobbio, P. Valente, R. Polizzi, C. De Vincentiis, M. Matarazzo, L. Saldamarco, F. Sacca, R. Napoli, M.G. Monti, R. D’Assante, A. Isidori, J. Isgaard, N. Ferrara, P.P. Filardi, F. Perticone, C. Vigorito, E. Bossone, A. Cittadini, T. Investigators, Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction. Int. J. Cardiol. 225, 1–3 (2016).  https://doi.org/10.1016/j.ijcard.2016.09.085 CrossRefGoogle Scholar
  3. 3.
    Arcopinto M., Salzano A., Giallauria F., Bossone E., Isgaard J., Marra A. M., Bobbio E., Vriz O., Aberg D. N., Masarone D., De Paulis A., Saldamarco L., Vigorito C., Formisano P., Niola M., Perticone F., Bonaduce D., Sacca L., Colao A., Cittadini A., Scompen T. T. O. (2017) Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the TOSCA. GHD Study. PLoS ONE 12 (1).  https://doi.org/10.1371/journal.pone.0170058
  4. 4.
    M. Arcopinto, E. Bobbio, E. Bossone, P. Perrone-Filardi, R. Napoli, L. Sacca, A. Cittadini, The GH/IGF-1 Axis in Chronic Heart Failure. Endocr. Metab. Immune Disord.-Drug Targets 13(1), 76–91 (2013).  https://doi.org/10.2174/1871530311313010010 CrossRefGoogle Scholar
  5. 5.
    M. Arcopinto, J. Isgaard, A.M. Marra, P. Formisano, E. Bossone, O. Vriz, C. Vigorito, L. Sacca, P.S. Douglas, A. Cittadini, IGF-1 predicts survival in chronic heart failure. Insights from the TOSCA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry. Int. J. Cardiol. 176(3), 1006–1008 (2014).  https://doi.org/10.1016/j.ijcard.2014.07.003 CrossRefGoogle Scholar
  6. 6.
    J. Isgaard, H. Wahlander, M.A. Adams, P. Friberg, Increased expression of growth-hormone receptor m-RNA and insulin-like growth-factor-I m-RNA in volume-overloaded hearts. Hypertension 23(6), 884–888 (1994).  https://doi.org/10.1161/01.hyp.23.6.884 CrossRefGoogle Scholar
  7. 7.
    P. Ponikowski, A.A. Voors, S.D. Anker, H. Bueno, J.G.F. Cleland, A.J.S. Coats, V. Falk, J.R. Gonzalez-Juanatey, V.P. Harjola, E.A. Jankowska, M. Jessup, C. Linde, P. Nihoyannopoulos, J.T. Parissis, B. Pieske, J.P. Riley, G.M.C. Rosano, L.M. Ruilope, F. Ruschitzka, F.H. Rutten, P. van der Meer, G. Filippatos, J.J.V. McMurray, V. Aboyans, S. Achenbach, S. Agewall, N. Al-Attar, J.J. Atherton, J. Bauersachs, A.J. Camm, S. Carerj, C. Ceconi, A. Coca, P. Elliott, C. Erol, J. Ezekowitz, C. Fernandez-Golfin, D. Fitzsimons, M. Guazzi, 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Fail. 18(8), 891–975 (2016).  https://doi.org/10.1002/ejhf.592 CrossRefGoogle Scholar
  8. 8.
    J. Niebauer, C.D. Pflaum, A.L. Clark, C.J. Strasburger, J. Hooper, P.A. Poole-Wilson, A.J.S. Coats, S.D. Anker, Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation. J. Am. Coll. Cardiol. 32(2), 393–397 (1998).  https://doi.org/10.1016/s0735-1097(98)00226-5 CrossRefGoogle Scholar
  9. 9.
    M. Spies, O. Nesic, R.E. Barrow, J.R. Perez-Polo, D.N. Herndon, Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound. Gene Ther. 8(18), 1409–1415 (2001).  https://doi.org/10.1038/sj.gt.3301543 CrossRefGoogle Scholar
  10. 10.
    M. Arcopinto, A. Salzano, J. Isgaard, A. Cittadini, Hormone replacement therapy in heart failure. Curr. Opin. Cardiol. 30(3), 277–284 (2015).  https://doi.org/10.1097/hco.0000000000000166 CrossRefGoogle Scholar
  11. 11.
    E. Bossone, M. Arcopinto, M. Iacoviello, V. Triggiani, F. Cacciatore, C. Maiello, G. Limongelli, D. Masarone, F. Perticone, A. Sciacqua, P. Perrone-Filardi, A. Mancini, M. Volterrani, O. Vriz, R. Castello, A. Passantino, M. Campo, P.A. Modesti, A. De Giorgi, I. Monte, A. Puzzo, A. Ballotta, L. Caliendo, R. D’Assante, A.M. Marra, A. Salzano, T. Suzuki, A. Cittadini, T. Investigators, Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the TOSCA. Registry. Intern. Emerg. Med. 13(5), 661–671 (2018).  https://doi.org/10.1007/s11739-018-1844-8 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Roberta D’Assante
    • 1
  • Raffaele Napoli
    • 1
  • Andrea Salzano
    • 2
  • Carlotta Pozza
    • 3
  • Alberto Maria Marra
    • 4
  • Michele Arcopinto
    • 1
    • 5
  • Giuseppe Perruolo
    • 1
  • Salvatore Milano
    • 6
  • Pietro Formisano
    • 1
  • Lavinia Saldamarco
    • 5
  • Plinio Cirillo
    • 7
  • Antonio Cittadini
    • 1
    Email author
  1. 1.Department of Translational Medical Sciences, Unit of Internal Medicine, Metabolism & RehabilitationFederico II University of NaplesNaplesItaly
  2. 2.Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research CentreUniversity of Leicester, Glenfield HospitalLeicesterUK
  3. 3.Department of Experimental MedicineSapienza University of RomeRomeItaly
  4. 4.IRCCS SDNNaplesItaly
  5. 5.Emergency DepartmentA Cardarelli HospitalNaplesItaly
  6. 6.Department of Laboratory Medicine, CoreLab, AOUP “P. Giaccone”University of PalermoPalermoItaly
  7. 7.Department of Advanced Biomedical Sciences, Division of CardiologyFederico II University of NaplesNaplesItaly

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