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Endocrine

, Volume 66, Issue 2, pp 381–385 | Cite as

Testosterone levels after treatment with urofollitropin in infertile patients with idiopathic mild reduction of testicular volume

  • Sandro La VigneraEmail author
  • Rosita A. Condorelli
  • Rossella Cannarella
  • Laura Cimino
  • Laura Mongioi’
  • Ylenia Duca
  • Filippo Giacone
  • Aldo E. Calogero
Original Article
  • 42 Downloads

Abstract

Introduction

A reduction of testicular volume (TV) represents an important clinical sign, which may hide sperm abnormalities and predispose to hypogonadism.

Aim

The primary purpose of this study was to evaluate the serum levels of total testosterone after treatment with urofollitropin in selected patients with male infertility and idiopathic mild reduction of testicular volume.

Methods

In this 1-year-long prospective design, patients with abnormal sperm parameters, mild reduction in TV (8–12 mL) and normal gonadotropin, and total testosterone (TT) serum levels were recruited in this study. Patients treated for 4 months with urofollitropin were included in group A, those treated with intracytoplasmatic sperm injection due to a female-factor infertility were included in group B. Hormone values, sperm parameters, and TV were detected at baseline (T0), after 4 (T1) and 12 months (T2) in group A and at T0 and T2 in group B.

Results

Group A (n = 80) showed increased follicle-stimulating hormone (FSH) at T1 and sperm morphology at T1 and T2 compared to T0 (all p < 0.05). Group B (n = 50) had lower TT and higher FSH levels at T2 compared to T0 (all p < 0.05). At T2, TT, VT, total sperm count, progressive motility, total motility, and sperm morphology were higher in group A compared to group B (all p < 0.05).

Conclusion

Reduced TV may predispose to infertility and hypogonadism. FSH treatment may improve Sertoli and Leydig cell function and prevent the development of hypogonadism.

Keywords

Testiculopathy Total testosterone Infertility Hypogonadism 

Abbreviations

FSH

follicle-stimulating hormone;

hCG

human chorionic gonadotropin;

LC

Leydig cell;

LH

luteinizing hormone;

O

oligozoospermia;

OA

Oligo-asthenozoospemia;

OAT

oligo-astheno-teratozoospermia;

SC

Sertoli cell;

TT

total testosterone;

TV

testicular volume.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval and consent to participate

All procedures involving human participants were in accordance with the ethical standard of institutional research committee and with Helsinki declaration.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Clinical and Experimental MedicineUniversity of CataniaCataniaItaly

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