, Volume 63, Issue 1, pp 167–170 | Cite as

Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis

  • Vincenzo De Sanctis
  • Ashraf T. Soliman
  • Duran Canatan
  • Salvatore Di Maio
  • Heba ElsedfyEmail author
  • Alaa Baioumi
  • Christos Kattamis
Research Letter

Although spontaneous fertility can occur in well-transfused and well-chelated patients, with β-thalassemia major (β-ΤΜ), the majority are sub fertile due to hypogonadotropic hypogonadism (HH), secondary to transfusional haemosiderosis [1]. Ιn several studies, 40 to 80% of β-ΤΜ patients reported to have arrested puberty, pubertal failure, sexual dysfunction, and infertility [1, 2].

In many non-thalassemic patients with HH, human chorionic gonadotropin (hCG) alone or in combination with human menopausal gonadotropin (hMG) induced spermatogenesis [3, 4, 5]. Very little is known about the induction of spermatogenesis in adolescents and young adult β-TM patients [6, 7]. In this study, we report the preliminary results of gonadotropin replacement for induction of spermatogenesis in five young adult β-TM patients with arrested puberty and acquired hypogonadotropic hypogonadism (AHH), complaining sexual dysfunction and fertility problems.

Patients and methods

Five young adult β-TM patients...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of Quisisana Hospital and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants, complaining sexual dysfunction and fertility problems, included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Vincenzo De Sanctis
    • 1
  • Ashraf T. Soliman
    • 2
  • Duran Canatan
    • 3
  • Salvatore Di Maio
    • 4
  • Heba Elsedfy
    • 5
    Email author
  • Alaa Baioumi
    • 5
  • Christos Kattamis
    • 6
  1. 1.Pediatric and Adolescent Outpatient Clinic, Quisisana HospitalFerraraItaly
  2. 2.Department of Pediatrics, Division of EndocrinologyAlexandria University Children’s HospitalAlexandriaEgypt
  3. 3.Thalassemia Diagnosis Center of Mediterranean Blood Diseases FoundationAntalyaTurkey
  4. 4.Emeritus Director in Pediatrics, Santobono-Pausilipon Children’s HospitalNaplesItaly
  5. 5.Department of PediatricsAin Shams UniversityCairoEgypt
  6. 6.First Department of PaediatricsNational Kapodistrian University of AthensAthensGreece

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