Alterations in levels of intermediate-chained acylcarnitines associate with weight-gain following reestablishment of euthyroidism in Graves’ disease
- 43 Downloads
Graves’ disease (GD) is an autoimmune disease resulting in increased production of thyroid hormones. The disease is associated with a state of relative starvation that, despite of increased hunger and food intake, result in weight loss and muscle weakness . Fatty acid oxidation is increased due to a reduced sensitivity of carnitine palmitoyl transferase 1 (CPT1), a master regulator of lipid metabolism, to inhibition by malonyl-CoA [2, 3]. Moreover, increased expression and activity of this protein has been suggested in the disease [2, 3]. Hence, the disease is likely to result in exaggerated production of acylcarnitines, resulting in release of these intermediates into the circulation . In line with this, two recent studies have shown a marked reduction in acylcarnitine levels, particularly of those with intermediate chain length, following reinstatement of euthyroidism in GD [5, 6].
GD is treated by anti-thyroid medication, radioiodine or surgery and depending on...
Thanks to associate professor Bengt Hallengren for valuable discussion of the manuscript.
This work was supported by the Royal Physiographic Society, the Novo Nordisk-, Påhlsson-, the Swedish Diabetes-, Hjelt- and Crafoord Foundations, the research funds of Malmö University Hospital, the Faculty of Medicine at Lund University, the Skåne Research Foundation, the Swedish Research Council Strategic Research Area Exodiab (2009-1039) and Linnaeus grant (349-2006-237), and the Swedish Foundation for Strategic Research (IRC15-0067).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 1.G. Dimitriadis, P. Mitrou, V. Lambadiari, E. Boutati, E. Maratou, E. Koukkou, D. Panagiotakos, N. Tountas, T. Economopoulos, S.A. Raptis, Insulin-stimulated rates of glucose uptake in muscle in hyperthyroidism: the importance of blood flow. J. Clin. Endocrinol. Metab. 93(6), 2413–2415 (2008)CrossRefGoogle Scholar
- 10.M. Ng, T. Fleming, M. Robinson, B. Thomson, N. Graetz, C. Margono, E.C. Mullany, S. Biryukov, C. Abbafati, S.F. Abera, J.P. Abraham, N.M. Abu-Rmeileh, T. Achoki, F.S. AlBuhairan, Z.A. Alemu, R. Alfonso, M.K. Ali, R. Ali, N.A. Guzman, W. Ammar, P. Anwari, A. Banerjee, S. Barquera, S. Basu, D.A. Bennett, Z. Bhutta, J. Blore, N. Cabral, I.C. Nonato, J.C. Chang, R. Chowdhury, K.J. Courville, M.H. Criqui, D.K. Cundiff, K.C. Dabhadkar, L. Dandona, A. Davis, A. Dayama, S.D. Dharmaratne, E.L. Ding, A.M. Durrani, A. Esteghamati, F. Farzadfar, D.F. Fay, V.L. Feigin, A. Flaxman, M.H. Forouzanfar, A. Goto, M.A. Green, R. Gupta, N. Hafezi-Nejad, G.J. Hankey, H.C. Harewood, R. Havmoeller, S. Hay, L. Hernandez, A. Husseini, B.T. Idrisov, N. Ikeda, F. Islami, E. Jahangir, S.K. Jassal, S.H. Jee, M. Jeffreys, J.B. Jonas, E.K. Kabagambe, S.E. Khalifa, A.P. Kengne, Y.S. Khader, Y.H. Khang, D. Kim, R.W. Kimokoti, J.M. Kinge, Y. Kokubo, S. Kosen, G. Kwan, T. Lai, M. Leinsalu, Y. Li, X. Liang, S. Liu, G. Logroscino, P.A. Lotufo, Y. Lu, J. Ma, N.K. Mainoo, G.A. Mensah, T.R. Merriman, A.H. Mokdad, J. Moschandreas, M. Naghavi, A. Naheed, D. Nand, K.M. Narayan, E.L. Nelson, M.L. Neuhouser, M.I. Nisar, T. Ohkubo, S.O. Oti, A. Pedroza, D. Prabhakaran, N. Roy, U. Sampson, H. Seo, S.G. Sepanlou, K. Shibuya, R. Shiri, I. Shiue, G.M. Singh, J.A. Singh, V. Skirbekk, N.J. Stapelberg, L. Sturua, B.L. Sykes, M. Tobias, B.X. Tran, L. Trasande, H. Toyoshima, S. van de Vijver, T.J. Vasankari, J.L. Veerman, G. Velasquez-Melendez, V.V. Vlassov, S.E. Vollset, T. Vos, C. Wang, X. Wang, E. Weiderpass, A. Werdecker, J.L. Wright, Y.C. Yang, H. Yatsuya, J. Yoon, S.J. Yoon, Y. Zhao, M. Zhou, S. Zhu, A.D. Lopez, C.J. Murray, E. Gakidou, Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384(9945), 766–781 (2014)CrossRefGoogle Scholar
- 11.M.G. Schooneman, A. Napolitano, S.M. Houten, G.K. Ambler, P.R. Murgatroyd, S.R. Miller, C.E. Hollak, C.Y. Tan, S. Virtue, A. Vidal-Puig, D.J. Nunez, M.R. Soeters, Assessment of plasma acylcarnitines before and after weight loss in obese subjects. Arch. Biochem. Biophys. 606, 73–80 (2016)CrossRefGoogle Scholar