, Volume 62, Issue 2, pp 440–447 | Cite as

An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

  • Yasemin AydoğanEmail author
  • Mustafa Altay
  • Oktay Ünsal
  • Veysel Kaplanoğlu
  • Yavuz Çağır
  • Canan Yıldız
  • Esin Beyan
  • Selma Uysal Ramadan
Original Article



Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA).

Materials and methods

50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery.


PWV was found to be significantly higher in the euthyroid nodular goiter group (p < 0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p = 0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data.


We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.


Euthyroid nodular goiter Insulin resistance Strain index Pulse wave velocity 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Research Ethics Committee of University of Health Sciences, Keçiören SUAM (date 13.04.2016 and reference number 1124). All the methods used in the study were carried out in accordance with the approved guidelines and Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yasemin Aydoğan
    • 1
    Email author
  • Mustafa Altay
    • 2
  • Oktay Ünsal
    • 3
  • Veysel Kaplanoğlu
    • 4
  • Yavuz Çağır
    • 5
  • Canan Yıldız
    • 6
  • Esin Beyan
    • 7
  • Selma Uysal Ramadan
    • 8
  1. 1.Zonguldak Devrek State HospitalZonguldakTurkey
  2. 2.Department of EndocrinologyKeçiören Training and Research HospitalAnkaraTurkey
  3. 3.Department of NefrologyUludağ University Medical Faculty HospitalBursaTurkey
  4. 4.Department of RadiologyKeçiören Training ad Research HospitalAnkaraTurkey
  5. 5.Çankırı Çerkeş State HospitalÇankırıTurkey
  6. 6.Aydın Didim State HospitalAydınTurkey
  7. 7.Department of Internal MedicineKeçiören Training and Research HospitalAnkaraTurkey
  8. 8.Deparment of RadiologyKeçiören Training and Research HospitalAnkaraTurkey

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