Intermittent administration of PTH induces the expression of osteocalcin and BMP-2 on choroid plexus cells associated with suppression of sclerostin, TGF-β1, and Na+K+ATPase
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The parathyroid hormone (PTH) is a key hormone that acts on the regulation of calcium homeostasis and bone turnover. Despite evidence that this hormone has a dual action, for example, anabolic or catabolic effects, researchers have described that when the PTH is administrated in an intermittent form, it acts in favor of bone formation, which is why the Food and Drug Administration supports it for the treatment of osteoporosis . According to this premise, some experiments with model animals have reinforced the hypothesis that this therapeutic approach may be a likely alternative to induce osteoneogenesis in areas that have been lost due to trauma, intra bonny cysts, or neoplasia .
The positive action of PTH signaling on bone is mediated by a G protein–coupled receptor referred to as PTH receptor-1 (PTH1R). In this way, the PTH/PTH1R interaction stimulates the Gαs-mediated activation of adenylate cyclase, which, in turn, enhances bone morphogenetic protein-2 (BMP-2)...
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The authors declare that they have no competing interests.
Approval from the institutional Animal Care Committee was obtained (protocol #296-2016). All applicable international and institutional Animal Care Committee guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.
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