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Endocrine

, Volume 59, Issue 3, pp 690–693 | Cite as

Lower urinary tract symptoms (LUTS) in males with type 2 diabetes recently treated with SGLT2 inhibitors—overlooked and overwhelming? A retrospective case series

  • Nino Cristiano Chilelli
  • Giuseppe Bax
  • Giulio Bonaldo
  • Eugenio Ragazzi
  • Massimo Iafrate
  • Filiberto Zattoni
  • Federico Bellavere
  • Annunziata LapollaEmail author
Research Letter

Introduction

As outlined in the latest recommendations for patients with type 2 diabetes (DM2), sodium glucose cotransporter 2 inhibitors (SGLT2i) can be added on treatments with metformin or sulfonylurea plus metformin if glycemic goals are not met [1]. Genital and urinary infections are well-known side effects of SGLT2i, with reported odds ratios in the range of 3.21–5.23, compared with placebo [2, 3].

Lower urinary tract symptoms (LUTS) are urological complications occurring in patients with DM2—males in particular—, whereas little is known about their prevalence in patients treated with SGLT2i [4]. This association is of particular interest because a symptom such as polyuria—often reported by patients starting treatment with SGLT2i—may be the sign of a urological predisposing conditions, rather than a side effect of a new treatment.

Hence this case-series on male patients who had recently started treatment with SGLT2i, to assess the prevalence of new-onset LUTS. We documented any...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Diabetology and Dietetics Unit, Department of MedicineUniversity of PadovaPadovaItaly
  2. 2.Urology Clinic, Department of Oncological and Surgical SciencesUniversity of PadovaPadovaItaly
  3. 3.Department of Pharmaceutical and Pharmacological SciencesUniversity of PadovaPadovaItaly
  4. 4.Rizzola Foundation HospitalVeneziaItaly

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