Clinical Reviews in Bone and Mineral Metabolism

, Volume 16, Issue 4, pp 131–141 | Cite as

Tendon Healing in the Context of Complex Fractures

  • Elahe Ganji
  • Megan L. KillianEmail author
Part of the following topical collections:
  1. Fracture


Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Tendon injuries that occur at the time of bone fracture have long-term ramifications on musculoskeletal health, yet these injuries are often disregarded in clinical treatment and diagnosis for patients with bone fractures as well as in basic science approaches for understanding bone repair processes. Delayed assessment of soft tissue injuries during evaluation of trauma can lead to chronic pain, dysfunction, and delayed bone healing even following successful fracture repair, highlighting the importance of identifying and treating damaged tendons early. Treatment strategies for bone repair, such as mechanical stabilization and biological therapeutics, can impact tendon healing and function. Because poor tendon healing following complex fracture can significantly impact the function of tendon during bone fracture healing, a need exists to understand the healing process of complex fractures more broadly, beyond the healing of bone. In this review, we explored the mechanical and biological interaction of bone and tendon in the context of complex fracture, as well as the relevance and potential ramifications of tendon damage following bone fracture, which has particular impact on patients that experience complex fractures, such as from combat, automobile accidents, and other trauma.


Complex fracture Tendon Repair Stability Growth factors 



This research is supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30GM103333 (PI: Buchanan). NIH is a federal medical research agency supporting public health-related scientific studies throughout the USA.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Approval

No ethics committee approval was required in undertaking this work.

Informed Consent

No informed consent was required in undertaking this work as work did not involve any human participants or animals.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringUniversity of DelawareNewarkUSA
  2. 2.Department of Mechanical EngineeringUniversity of DelawareNewarkUSA

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