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Effect of the BDNF Val66Met Polymorphism on Regional Gray Matter Volumes and Cognitive Function in the Chinese Population

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Abstract

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is common and influences the activity-dependent secretion of BDNF, which is critical for neuronal plasticity and survival. This study investigated the genetic effect of the BDNF Val66Met polymorphism on cognitive function and regional gray matter (GM) volume in a healthy Chinese population (n = 330). Voxel-based morphometry (VBM)-optimized analysis was used. There was no significant difference in the neuropsychological performances among the three BDNF genotypic groups. VBM analyses demonstrated that Met homozygotes had greater GM volumes than Val homozygotes in the left medial frontal gyrus, the left middle temporal gyrus, the left cerebellum, and the right middle temporal gyrus, and had larger GM volumes than Val/Met heterozygotes in the left middle temporal gyrus, the left inferior temporal gyrus, and the right superior frontal gyrus. Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population.

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Acknowledgments

This work was supported by Grants V101C-006 from Taipei Veterans General Hospital, Taiwan, and Grant NSC 101-2314-B-075-040, NSC 100-2628-E-010-002-MY3 and NSC 101-2321-B-010-026 from National Science Council Grant, Taiwan. We thank Ms Ashley for English editing.

Conflict of interest

All authors have no actual or potential conflicts of interest within 3 years of beginning the work submitted that could inappropriately influence the work.

Ethical standard

This study was approved by the Institutional Review Board of Taipei Veterans General Hospital. Informed consent was obtained from all subjects prior to commencement.

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Authors and Affiliations

  1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan

    Mu-En Liu

  2. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

    Chu-Chung Huang & Ching-Po Lin

  3. Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan

    Mu-Hong Chen, Albert C. Yang, Pei-Chi Tu, Chen-Jee Hong, Jen-Ping Hwang & Shih-Jen Tsai

  4. School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Albert C. Yang, Chen-Jee Hong, Jen-Ping Hwang & Shih-Jen Tsai

  5. Center for Dynamical Biomarkers and Translational Medicine, National Central University, Jungli, Taiwan

    Albert C. Yang

  6. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

    Pei-Chi Tu

  7. Taipei Veterans Home, New-Taipei City, Taiwan

    Heng-Liang Yeh

  8. Institute of Neuroscience, School of Life Science, National Yang-Ming University, 155, Li-Nong St. 112, Taipei, Taiwan

    Ching-Po Lin

  9. Department of Pathology, Tao-Yuan Veterans Hospital, Taoyuan, Taoyuan County, Taiwan

    Jin-Fan Chen

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  1. Mu-En Liu
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Correspondence to Ching-Po Lin or Shih-Jen Tsai.

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Liu, ME., Huang, CC., Chen, MH. et al. Effect of the BDNF Val66Met Polymorphism on Regional Gray Matter Volumes and Cognitive Function in the Chinese Population. Neuromol Med 16, 127–136 (2014). https://doi.org/10.1007/s12017-013-8265-7

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