The Role of Home Environments in Allergic Disease
Abstract
Allergic diseases are surprisingly common, chronic health conditions. The primary location where the vast majority of people are exposed to allergens and other substances is in their home. This means it is important to understand home environments and how a home’s systems function and interact—and that how we occupy these spaces plays a crucial role in both environmental exposure and management of allergic disease. This review provides an overview of what is understood about home environmental exposure and its impact on our health, and proposes a systematic process for using a patient’s environmental history to develop individualized, manageable and cost-effective recommendations. Once occupant-related information has been gathered, a home environmental exposure assessment should be performed focused on identifying the relationships between any identified sources of contaminants and the housing systems, and conditions that may be contributing to exposure. The results and recommendations from this assessment can then be used to guide exposure-reduction efforts by patients and/or their caregivers in an effort to improve disease management. In this review, we’ll discuss three different types of home interventions—active, which must be routinely performed by the patient and/or caregiver, passive, which are interventions that work without routine, direct interaction from the homeowner, and behavioral changes in how the home environment is cleaned and maintained for long-term reduction of allergens. In this review, and others evaluated for this discussion, a significant number of home environmental assessment and intervention programs were shown to be cost effective, with the majority of programs showing a net positive return on investment. It is important to recognize that to be cost effective, the level and intensity of services offered through home visit programs need be stratified, based on the estimated health risks of the patient, in order to tailor the assessment and target the interventions to a patient's needs while maximizing cost effectiveness.
Keywords
Environment Asthma Allergy Home assessment Intervention AllergensNotes
Acknowledgements
The work of the authors has been supported by the U.S. Dept. of Housing and Urban Development's Office of Lead Hazard Control and Healthy Homes.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
This article does not contain any studies with human participants or animals performed by any of the authors.
References
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
- 1.Anandan C (2010) Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 65(2):152–67Google Scholar
- 2.Matsui EC, Abramson SL, Sandel MT (2016) Section on allergy and immunology; council on environmental health, indoor environmental control practices and asthma management. Pediatrics 138(5)Google Scholar
- 3.Sublett JL (2005) The environment and risk factors for atopy. Curr Allergy Asthma Rep 5(6):445–450PubMedCrossRefGoogle Scholar
- 4.Thomsen SF (2015) Epidemiology and natural history of atopic diseases. Eur Clin Respir J 2Google Scholar
- 5.Klepeis NE et al (2001) The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol 11(3):231–252PubMedCrossRefGoogle Scholar
- 6.Salo PM, Arbes SJ Jr, Crockett PW, Thorne PS, Cohn RD, Zeldin DC (2008) Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol 121(3):678–684 e2PubMedPubMedCentralCrossRefGoogle Scholar
- 7.Jang J, Gary Chan KC, Huang H, Sullivan SD (2013) Trends in cost and outcomes among adult and pediatric patients with asthma: 2000-2009. Ann Allergy Asthma Immunol 111(6):516–522PubMedCrossRefGoogle Scholar
- 8.WHO (2009) Guidelines for indoor air quality: dampness and mould. World Health Organization, GenevaGoogle Scholar
- 9.Mendell Mj Fau- Mirer, A.G., et al., Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ Health Perspect, 2011. 119(6): p. 748–756PubMedPubMedCentralCrossRefGoogle Scholar
- 10.Krieger J, Higgins DL (2002) Housing and health: time again for public health action. Am J Public Health 92(5):758–768PubMedPubMedCentralCrossRefGoogle Scholar
- 11.Portnoy J et al (2012) Environmental assessment and exposure control: a practice parameter—furry animals. Ann Allergy Asthma Immunol 108(4):223 e1–15PubMedCrossRefGoogle Scholar
- 12.Portnoy J et al (2013) Environmental assessment and exposure reduction of cockroaches: a practice parameter. J Allergy Clin Immunol 132(4):802–8 e1–25PubMedCrossRefGoogle Scholar
- 13.Portnoy J, Miller JD, Williams PB, Chew GL, Miller JD, Zaitoun F, Phipatanakul W, Kennedy K, Barnes C, Grimes C, Larenas-Linnemann D, Sublett J, Bernstein D, Blessing-Moore J, Khan D, Lang D, Nicklas R, Oppenheimer J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Joint Taskforce on Practice Parameters, Practice Parameter Workgroup (2013) Environmental assessment and exposure control of dust mites: a practice parameter. Ann Allergy Asthma Immunol 111(6):465–507PubMedPubMedCentralCrossRefGoogle Scholar
- 14.Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, Bernstein D, Blessing-Moore J, Cox L, Khan D, Lang D, Nicklas R, Oppenheimer J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Sublett J, Bernstein J, Grimes C, Miller JD, Seltzer J, Joint Task Force on Practice Parameters (2012) Environmental assessment and exposure reduction of rodents: a practice parameter. Ann Allergy Asthma Immunol 109(6):375–387PubMedPubMedCentralCrossRefGoogle Scholar
- 15.Williams PB, Barnes CS, Portnoy JM, Barnes C, Baxi S, Grimes C, Horner WE, Kennedy K, Larenas-Linnemann D, Levetin E, Miller JD, Phipatanakul W, Portnoy JM, Scott J, Williams PB (2016) Innate and adaptive immune response to fungal products and allergens. J Allergy Clin Immunol Pract 4(3):386–395PubMedCrossRefGoogle Scholar
- 16.Larenas-Linnemann D, Baxi S, Phipatanakul W, Portnoy JM, Barnes C, Baxi S, Grimes C, Horner WE, Kennedy K, Larenas-Linnemann D, Levetin E, Miller JD, Phipatanakul W, Portnoy JM, Scott J, Williams PB (2016) Clinical evaluation and management of patients with suspected fungus sensitivity. J Allergy Clin Immunol Pract 4(3):405–414PubMedCrossRefGoogle Scholar
- 17.Clearing the Air: Asthma and Indoor Air Exposures. Institute of Medicine (US) Committee on the Assessment of Asthma and Indoor Air. National Academies Press (US), Washington (DC)Google Scholar
- 18.Kanchongkittiphon W, Mendell MJ, Gaffin JM, Wang G, Phipatanakul W (2015) Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine. Environ Health Perspect 123(1):6–20PubMedCrossRefGoogle Scholar
- 19.Burbank AJ, Sood AK, Kesic MJ, Peden DB, Hernandez ML (2017) Environmental determinants of allergy and asthma in early life. J Allergy Clin Immunol 140(1):1–12PubMedPubMedCentralCrossRefGoogle Scholar
- 20.Gilmour MI, Jaakkola MS, London SJ, Nel AE, Rogers CA (2006) How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect 114(4):627–633PubMedPubMedCentralCrossRefGoogle Scholar
- 21.Le Cann P et al (2011) Indoor environment and children’s health: recent developments in chemical, biological, physical and social aspects. Int J Hyg Environ Health 215(1):1–18PubMedCrossRefGoogle Scholar
- 22.Kim KH, Jahan SA, Kabir E (2013) A review on human health perspective of air pollution with respect to allergies and asthma. Environ Int 59:41–52PubMedCrossRefGoogle Scholar
- 23.Sherriff A, Farrow A, Golding J, the ALSPAC Study Team, Henderson J (2005) Frequent use of chemical household products is associated with persistent wheezing in pre-school age children. Thorax 60:45–49PubMedPubMedCentralCrossRefGoogle Scholar
- 24.Breysse PN, Diette GB, Matsui EC, Butz AM, Hansel NN, McCormack MC (2010) Indoor air pollution and asthma in children. Proc Am Thorac Soc 7(2):102–106PubMedPubMedCentralCrossRefGoogle Scholar
- 25.McCormack MC et al (2011) Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Ann Allergy Asthma Immunol 106(4):308–315PubMedPubMedCentralCrossRefGoogle Scholar
- 26.Ruokolainen L, Fyhrquist N, Haahtela T (2016) The rich and the poor: environmental biodiversity protecting from allergy. Curr Opin Allergy Clin Immunol 16(5):421–426PubMedCrossRefGoogle Scholar
- 27.Marsland BJ, Salami O (2015) Microbiome influences on allergy in mice and humans. Curr Opin Immunol 36:94–100PubMedCrossRefGoogle Scholar
- 28.Haahtela T et al (2013) The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J 6(1):3PubMedPubMedCentralCrossRefGoogle Scholar
- 29.Sokolowska M, Frei R, Lunjani N, Akdis CA, O’Mahony L (2018) Microbiome and asthma. Asthma Res Pract 4:1PubMedPubMedCentralCrossRefGoogle Scholar
- 30.Dannemiller KC, Gent JF, Leaderer BP, Peccia J (2016) Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children. Indoor Air 26(2):179–192PubMedCrossRefGoogle Scholar
- 31.Prussin AJ 2nd, Marr LC (2015) Sources of airborne microorganisms in the built environment. Microbiome 3:78PubMedPubMedCentralCrossRefGoogle Scholar
- 32.Ciaccio CE, Kennedy K, Portnoy JM (2012) A new model for environmental assessment and exposure reduction. Curr Allergy Asthma Rep 12(6):650–655PubMedPubMedCentralCrossRefGoogle Scholar
- 33.Jacobs DE, Brown MJ, Baeder A, Sucosky MS, Margolis S, Hershovitz J, Kolb L, Morley RL (2010) A systematic review of housing interventions and health: introduction, methods, and summary findings. J Public Health Manag Pract 16(5 Suppl):S5–S10PubMedCrossRefGoogle Scholar
- 34.Krieger J, Jacobs DE, Ashley PJ, Baeder A, Chew GL, Dearborn D, Hynes HP, Miller JD, Morley R, Rabito F, Zeldin DC (2010) Housing interventions and control of asthma-related indoor biologic agents: a review of the evidence. J Public Health Manag Pract 16(5 Suppl):S11–S20PubMedPubMedCentralCrossRefGoogle Scholar
- 35.Crocker DD, Kinyota S, Dumitru GG, Ligon CB, Herman EJ, Ferdinands JM, Hopkins DP, Lawrence BM, Sipe TA (2011) Effectiveness of home-based, multi-trigger, multicomponent interventions with an environmental focus for reducing asthma morbidity: a community guide systematic review. Am J Prev Med 41(2 Suppl 1):S5–S32PubMedCrossRefGoogle Scholar
- 36.•• Le Cann P et al (2017) Home environmental interventions for the prevention or control of allergic and respiratory diseases: what really works. J Allergy Clin Immunol Pract 5(1):66–79PubMedCrossRefGoogle Scholar
- 37.Kattan M, Stearns SC, Crain EF, Stout JW, Gergen PJ, Evans R III, Visness CM, Gruchalla RS, Morgan WJ, O'Connor GT, Mastin JP, Mitchell HE (2005) Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma. J Allergy Clin Immunol 116(5):1058–1063PubMedCrossRefGoogle Scholar
- 38.Wu F, Takaro TK (2007) Childhood asthma and environmental interventions. Environ Health Perspect 115(6):971–975PubMedPubMedCentralCrossRefGoogle Scholar
- 39.Nurmagambetov TA, Barnett SBL, Jacob V, Chattopadhyay SK, Hopkins DP, Crocker DD, Dumitru GG, Kinyota S (2011) Economic value of home-based, multi-trigger, multicomponent interventions with an environmental focus for reducing asthma morbidity a community guide systematic review. Am J Prev Med 41(2 Suppl 1):S33–S47PubMedCrossRefGoogle Scholar
- 40.Hsu J, Wilhelm N, Lewis L, Herman E (2016) Economic evidence for US asthma self-management education and home-based interventions. J Allergy Clin Immunol Pract 4(6):1123–1134 e27 PubMedPubMedCentralCrossRefGoogle Scholar
- 41.Chan-Yeung M, Manfreda J, Dimich-Ward H, Ferguson A, Watson W, Becker A (2000) A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med 154(7):657–663PubMedCrossRefGoogle Scholar
- 42.de Blay F, Birba E (2003) Controlling indoor allergens. Curr Opin Allergy Clin Immunol 3(3):165–168PubMedCrossRefGoogle Scholar
- 43.McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K (2005) Educational intervention to control cockroach allergen exposure in the homes of Hispanic children in Los Angeles: results of the La Casa study. Clin Exp Allergy 35(4):426–433PubMedCrossRefGoogle Scholar
- 44.Bryant-Stephens T, Li Y (2008) Outcomes of a home-based environmental remediation for urban children with asthma. J Natl Med Assoc 100(3):306–316PubMedCrossRefGoogle Scholar
- 45.Parker EA, Israel BA, Robins TG, Mentz G, Xihong Lin, Brakefield-Caldwell W, Ramirez E, Edgren KK, Salinas M, Lewis TC (2008) Evaluation of community action against asthma: a community health worker intervention to improve children’s asthma-related health by reducing household environmental triggers for asthma. Health Educ Behav 35(3):376–395PubMedCrossRefGoogle Scholar
- 46.Luczynska C, Tredwell E, Smeeton N, Burney P (2003) A randomized controlled trial of mite allergen-impermeable bed covers in adult mite-sensitized asthmatics. Clin Exp Allergy 33:1648–1653PubMedCrossRefGoogle Scholar
- 47.Francis H, Fletcher G, Anthony C, Pickering C, Oldham L, Hadley E, Custovic A, Niven R (2003) Clinical effects of air filters in homes of asthmatic adults sensitized and exposed to pet allergens. Clin Exp Allergy 33(1):101–105PubMedCrossRefGoogle Scholar
- 48.Halken S (2004) Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatr Allergy Immunol 15(Suppl 16):4–5 9–32PubMedGoogle Scholar
- 49.Popplewell EJ, Innes VA, Lloyd-Hughes S, Jenkins EL, Khdir K, Bryant TN, Warner JO, Warner JA (2000) The effect of high-efficiency and standard vacuum-cleaners on mite, cat and dog allergen levels and clinical progress. Pediatr Allergy Immunol 11(3):142–148PubMedCrossRefGoogle Scholar
- 50.Warner JA, Frederick JM, Bryant TN, Weich C, Raw GJ, Hunter C, Stephend FR, McIntyre DA, Warner JO (2000) Mechanical ventilation and high-efficiency vacuum cleaning: a combined strategy of mite and mite allergen reduction in the control of mite-sensitive asthma. J Allergy Clin Immunol 105(1 Pt 1):75–82PubMedCrossRefGoogle Scholar
- 51.Somerville M, Mackenzie I, Owen P, Miles D (2000) Housing and health: does installing heating in their homes improve the health of children with asthma? Public Health 114(6):434–439PubMedGoogle Scholar
- 52.Wakefield M, Banham D, McCaul K, Martin J, Ruffin R, Badcock N, Roberts L (2002) Effect of feedback regarding urinary cotinine and brief tailored advice on home smoking restrictions among low-income parents of children with asthma: a controlled trial. Prev Med 34(1):58–65PubMedCrossRefGoogle Scholar
- 53.Krieger JW, Takaro TK, Song L, Weaver M (2005) The Seattle-King County Healthy Homes Project: a randomized, controlled trial of a community health worker intervention to decrease exposure to indoor asthma triggers. Am J Public Health 95(4):652–659PubMedPubMedCentralCrossRefGoogle Scholar
- 54.Carter MC, Perzanowski MS, Raymond A, Platts-Mills TAE (2001) Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol 108(5):732–737PubMedCrossRefGoogle Scholar
- 55.Schonberger HJ et al (2004) Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens—a randomized trial. Clin Exp Allergy 34(7):1024–1031PubMedCrossRefGoogle Scholar
- 56.Adgate JL, Ramachandran G, Cho SJ, Ryan AD, Grengs J (2008) Allergen levels in inner city homes: baseline concentrations and evaluation of intervention effectiveness. J Expo Sci Environ Epidemiol 18(4):430–440PubMedCrossRefGoogle Scholar
- 57.Howden-Chapman P, Matheson A, Crane J, Viggers H, Cunningham M, Blakely T, Cunningham C, Woodward A, Saville-Smith K, O’Dea D, Kennedy M, Baker M, Waipara N, Chapman R, Davie G (2007) Effect of insulating existing houses on health inequality: cluster randomised study in the community. BMJ 334(7591):460PubMedPubMedCentralCrossRefGoogle Scholar
- 58.Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, Breysse P, Buckley T, Diette G, Merriman B, Krishnan JA (2005) Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Ann Allergy Asthma Immunol 95(6):518–524PubMedCrossRefGoogle Scholar
- 59.Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, Greenberg SJ, Vesper SJ, Allan T (2006) Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environ Health Perspect 114(10):1574–1580PubMedPubMedCentralCrossRefGoogle Scholar
- 60.Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans R 3rd, Stout J, Malindzak G, Smartt E, Plaut M, Walter M, Vaughn B, Mitchell H, Inner-City Asthma Study Group (2004) Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 351(11):1068–1080PubMedCrossRefGoogle Scholar
- 61.Schatz M, Zeiger RS (2012) Telephone-based environmental control interventions in asthmatic patients: what are patients willing to do? Ann Allergy Asthma Immunol 109(2):99–102PubMedCrossRefGoogle Scholar
- 62.DiMango E, Serebrisky D, Narula S, Shim C, Keating C, Sheares B, Perzanowski M, Miller R, DiMango A, Andrews H, Merle D, Liu X, Calatroni A, Kattan M (2016) Individualized household allergen intervention lowers allergen level but not asthma medication use: a randomized controlled trial. J Allergy Clin Immunol Pract 4(4):671–679 e4PubMedPubMedCentralCrossRefGoogle Scholar
- 63.Arbes SJ Jr, Sever M, Archer J, Long EH, Gore JC, Schal C, Walter M, Nuebler B, Vaughn B, Mitchell H, Liu E, Collette N, Adler P, Sandel M, Zeldin DC (2003) Abatement of cockroach allergen (Bla g 1) in low-income, urban housing: a randomized controlled trial. J Allergy Clin Immunol 112(2):339–345PubMedCrossRefGoogle Scholar
- 64.Breysse J, Dixon S, Gregory J, Philby M, Jacobs DE, Krieger J (2014) Effect of weatherization combined with community health worker in-home education on asthma control. Am J Public Health 104(1):e57–e64PubMedPubMedCentralCrossRefGoogle Scholar
- 65.Celano MP, Holsey CN, Kobrynski LJ (2012) Home-based family intervention for low-income children with asthma: a randomized controlled pilot study. J Fam Psychol 26(2):171–178PubMedCrossRefGoogle Scholar
- 66.Mankikar D, Campbell C, Greenberg R (2016) Evaluation of a home-based environmental and educational intervention to improve health in vulnerable households: Southeastern Pennsylvania Lead and Healthy Homes Program. Int J Environ Res Public Health 13(9):900PubMedCentralCrossRefPubMedGoogle Scholar
- 67.Butz AM, Matsui EC, Breysse P, Curtin-Brosnan J, Eggleston P, Diette G, Williams D, Yuan J, Bernert JT, Rand C (2011) A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Arch Pediatr Adolesc Med 165(8):741–748PubMedCrossRefGoogle Scholar
- 68.Chan-Yeung M, Ferguson A, Watson W, Dimich-Ward H, Rousseau R, Lilley M, DyBuncio A, Becker A (2005) The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol 116(1):49–55PubMedCrossRefGoogle Scholar
- 69.Vojta PJ, Randels SP, Stout J, Muilenberg M, Burge HA, Lynn H, Mitchell H, O'Connor GT, Zeldin DC (2001) Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes. Environ Health Perspect 109(8):815–819PubMedPubMedCentralCrossRefGoogle Scholar
- 70.Causer SM, Lewis RD, Batek JM, Ong KH (2004) Influence of wear, pile height, and cleaning method on removal of mite allergen from carpet. J Occup Environ Hyg 1(4):237–242PubMedCrossRefGoogle Scholar
- 71.Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, Britton J, Strachan D, Howarth P, Altmann D, Frost C, Custovic A, Medical Research Council General Practice Research Framework (2003) Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med 349(3):225–236PubMedCrossRefGoogle Scholar
- 72.Levy JI, Brugge D, Peters JL, Clougherty JE, Saddler SS (2006) A community-based participatory research study of multifaceted in-home environmental interventions for pediatric asthmatics in public housing. Soc Sci Med 63(8):2191–2203PubMedCrossRefGoogle Scholar
- 73.Klinnert MD, Liu AH, Pearson MR, Tong S, Strand M, Luckow A, Robinson JAL (2007) Outcome of a randomized multifaceted intervention with low-income families of wheezing infants. Arch Pediatr Adolesc Med 161(8):783–790PubMedCrossRefGoogle Scholar
- 74.Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P, Simpson A, Custovic A (2004) Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 170(4):433–439PubMedCrossRefGoogle Scholar
- 75.Carrillo G, Perez-Patron MJ, Lucio RL, Cabrera L, Trevino A, Xu X, Mier N (2017) The benefits and challenges of managing asthma in Hispanic families in South Texas: a mixed-methods study. Front Public Health 5:150PubMedPubMedCentralCrossRefGoogle Scholar
- 76.Krieger J, Song L, Philby M (2015) Community health worker home visits for adults with uncontrolled asthma: the HomeBASE Trial randomized clinical trial. JAMA Intern Med 175(1):109–117PubMedCrossRefGoogle Scholar
- 77.Turyk M et al (2013) A multifaceted community-based asthma intervention in Chicago: effects of trigger reduction and self-management education on asthma morbidity. J Asthma 50(7):729–736PubMedCrossRefGoogle Scholar
- 78.Largo TW, Borgialli M, Wisinski CL, Wahl RL, Priem WF (2011) Healthy Homes University: a home-based environmental intervention and education program for families with pediatric asthma in Michigan. Public Health Rep 126(Suppl 1):14–26PubMedPubMedCentralCrossRefGoogle Scholar
- 79.Jhun I, Gaffin JM, Coull BA, Huffaker MF, Petty CR, Sheehan WJ, Baxi SN, Lai PS, Kang CM, Wolfson JM, Gold DR, Koutrakis P, Phipatanakul W (2017) School environmental intervention to reduce particulate pollutant exposures for children with asthma. J Allergy Clin Immunol Pract 5(1):154–159 e3PubMedCrossRefGoogle Scholar
- 80.Schonberger HJ et al (2005) The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma. Eur Respir J 25(4):660–670PubMedCrossRefGoogle Scholar
- 81.McClure N, Lutenbacher M, O'Kelley E, Dietrich MS (2017) Enhancing pediatric asthma care and nursing education through an academic practice partnership. J Pediatr Nurs 36:64–69PubMedCrossRefGoogle Scholar
- 82.Butz AM, Syron L, Johnson B, Spaulding J, Walker M, Bollinger ME (2005) Home-based asthma self-management education for inner city children. Public Health Nurs 22(3):189–199PubMedCrossRefGoogle Scholar
- 83.Ahluwalia SK, Matsui EC (2018) Indoor environmental interventions for furry pet allergens, pest allergens, and mold: looking to the future. J Allergy Clin Immunol Pract 6(1):9–19PubMedPubMedCentralCrossRefGoogle Scholar
- 84.Custovic A, Simpson BM, Simpson A, Hallam C, Craven M, Brutsche M, Woodcock A (2000) Manchester Asthma and Allergy Study: low-allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol 105(2 Pt 1):252–258PubMedCrossRefGoogle Scholar
- 85.Barnes CS, Horner WE, Kennedy K, Grimes C, Miller JD, Barnes C, Baxi S, Grimes C, Horner WE, Kennedy K, Larenas-Linnemann D, Levetin E, Miller JD, Phipatanakul W, Portnoy JM, Scott J, Williams PB (2016) Home assessment and remediation. J Allergy Clin Immunol Pract 4(3):423–431 e15PubMedCrossRefGoogle Scholar
- 86.•• Sauni R et al (2015) Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database Syst Rev 2:CD007897Google Scholar
- 87.Chew GL, Horner WE, Kennedy K, Grimes C, Barnes CS, Phipatanakul W, Larenas-Linnemann D, Miller JD, Environmental Allergens Workgroup (2016) Procedures to assist health care providers to determine when home assessments for potential mold exposure are warranted. J Allergy Clin Immunol Pract 4(3):417–422 e2 Google Scholar
- 88.Hyndman SJ et al (2000) A randomized trial of dehumidification in the control of house dust mite. Clin Exp Allergy 30(8):1172–1180PubMedCrossRefGoogle Scholar
- 89.Singh M, Jaiswal N (2013) Dehumidifiers for chronic asthma. Cochrane Database Syst Rev 6:CD003563Google Scholar
- 90.Sublett JL, Seltzer J, Burkhead R, Williams PB, Wedner HJ, Phipatanakul W, American Academy of Allergy, Asthma & Immunology Indoor Allergen Committee (2010) Air filters and air cleaners: rostrum by the American Academy of Allergy, Asthma & Immunology Indoor Allergen Committee. J Allergy Clin Immunol 125(1):32–38PubMedCrossRefGoogle Scholar
- 91.Wood RA (2002) Air filtration devices in the control of indoor allergens. Curr Allergy Asthma Rep 2(5):397–400PubMedCrossRefGoogle Scholar
- 92.Zimmerman GL, Olsen CG, Bosworth MF (2000) A ‘stages of change’ approach to helping patients change behavior. Am Fam Physician 61(5):1409–1416PubMedGoogle Scholar
- 93.Bellin MH, Land C, Newsome A, Kub J, Mudd SS, Bollinger ME, Butz AM (2017) Caregiver perception of asthma management of children in the context of poverty. J Asthma 54(2):162–172PubMedCrossRefGoogle Scholar
- 94.Weil CM, W S, Bauman LJ, Lynn H, Mitchell H, Lavigne J (1999) The relationship between psychosocial factors and asthma morbidity in inner-city children with asthma. Pediatrics 104(6):1274–1280PubMedCrossRefGoogle Scholar
- 95.Wilson J (2016) Home Rx: the health benefits of home performance. p. 65Google Scholar
- 96.Tonn B (2014) Health and household-related benefits attributable to the weatherization assistance program, Oak Ridge National Laboratory.p 181Google Scholar
- 97.(2007) Expert Panel Report 3 (EPR-3): Guidelines for the diagnosis and management of asthma—summary report J Allergy Clin Immunol, 2007 120(5 Suppl): p. S94–138Google Scholar
- 98.Gomez M, Reddy AL, Dixon SL, Wilson J, Jacobs DE (2017) A cost-benefit analysis of a state-funded healthy homes program for residents with asthma: findings from the New York State Healthy Neighborhoods Program. J Public Health Manag Pract 23(2):229–238PubMedCrossRefGoogle Scholar
- 99.Schatz M, Nakahiro R, Jones CH, Roth RM, Joshua A, Petitti D (2004) Asthma population management: development and validation of a practical 3-level risk stratification scheme. Am J Manag Care 10(1):25–32PubMedGoogle Scholar
- 100.Hanson JR, Lee BR, Williams DD, Murphy H, Kennedy K, DeLurgio SA Sr, Portnoy J, Reddy M (2016) Developing a risk stratification model for predicting future health care use in asthmatic children. Ann Allergy Asthma Immunol 116(1):26–30PubMedCrossRefGoogle Scholar
- 101.Luo G, Stone BL, Sakaguchi F, Sheng X, Murtaugh MA (2015) Using computational approaches to improve risk-stratified patient management: rationale and methods. JMIR Res Protoc 4(4):e128PubMedPubMedCentralCrossRefGoogle Scholar
- 102.Luo G, Sward K (2017) A roadmap for optimizing asthma care management via computational approaches. JMIR Med Inform 5(3):e32PubMedPubMedCentralCrossRefGoogle Scholar
- 103.Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB (2004) Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113(1):59–65PubMedCrossRefGoogle Scholar
- 104.Liu AH, Zeiger R, Sorkness C, Mahr T, Ostrom N, Burgess S, Rosenzweig JC, Manjunath RJ (2007) Development and cross-sectional validation of the childhood asthma control test. Allergy Clin Immunol 119(4):817–825CrossRefGoogle Scholar
- 105.Liu AH, Zeiger RS, Sorkness CA, Ostrom NK, Chipps BE, Rosa K, Watson ME, Kaplan MS, Meurer JR, Mahr TA, Blaiss MS, Piault-Louis E, McDonald J (2010) The Childhood Asthma Control Test: retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma. J Allergy Clin Immunol 126(2):267–273 273 e1Google Scholar
- 106.Postma J, Karr C, Kieckhefer G (2009) Community health workers and environmental interventions for children with asthma: a systematic review. J Asthma 46(6):564–576PubMedCrossRefGoogle Scholar
- 107.Raphael JL, Rueda A, Lion KC, Giordano TP (2013) The role of lay health workers in pediatric chronic disease: a systematic review. Acad Pediatr 13(5):408–420PubMedPubMedCentralCrossRefGoogle Scholar
- 108.Jack HE, Arabadjis SD, Sun L, Sullivan EE, Phillips RS (2017) Impact of community health workers on use of healthcare services in the United States: a systematic review. J Gen Intern Med 32(3):325–344PubMedCrossRefGoogle Scholar
- 109.Campbell JD, Brooks M, Hosokawa P, Robinson J, Song L, Krieger J (2015) Community health worker home visits for Medicaid-enrolled children with asthma: effects on asthma outcomes and costs. Am J Public Health 105(11):2366–2372PubMedPubMedCentralCrossRefGoogle Scholar
- 110.American Housing Survey (2015)Google Scholar
- 111.Schatz M, Zeiger RS (2010) Ineffectiveness of telephone-based environmental control intervention to improve asthma outcomes. J Allergy Clin Immunol 126(4):873–875PubMedCrossRefGoogle Scholar
- 112.•• Winn AK et al (2016) Efficacy of an in-home test kit in reducing dust mite allergen levels: results of a randomized controlled pilot study. J Asthma 53(2):133–138PubMedCrossRefGoogle Scholar
- 1.Nation Environmental Education Foundation, Washington DC. https://www.neefusa.org/resource/asthma-environmental-history-form, https://www.neefusa.org/resource/pediatric-environmental-history
- 2.National Healthy Home Training Center, Healthy Housing Solutions, Columbia, Maryland. http://healthyhousingsolutions.com/wp-content/uploads/2014/12/HHAPP_Ex_2_PEHA_Survey-Nov2013.pdf
- 3.National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://www.niehs.nih.gov/health/assets/docs_a_e/environmental_management_of_pediatric_asthma_guidelines_for_health_care_providers_508.pdf