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Clinical Reviews in Allergy & Immunology

, Volume 55, Issue 2, pp 217–236 | Cite as

Psychosocial Mediators of Change and Patient Selection Factors in Oral Immunotherapy Trials

  • Audrey Dunn Galvin
  • J.O’B. Hourihane
Article

Abstract

Health-related quality of life (HRQL) is influenced by physiological, psychological, and environmental variables and can be best understood by considering the interactions of factors that cut across multiple levels. One of the most important issues relating to treatment in food allergy is to identify, describe, and define predictors that may contribute to modify HRQL outcomes. The research presented demonstrates that measures of HRQL are able to distinguish key features of known groups (e.g. relating to reaction severity, treatment, allergen type/number, expectation of outcome) and delineate impact on hitherto unknown groups (e.g. relating to personality types and coping styles). This heterogeneity may explain why HRQL or other patient-related outcomes may differ in individuals during, or following any treatment or intervention. Patient-reported outcomes are relatively poorly defined to date. Since HRQL has only been studied in relatively few oral immunotherapy trials to date, primarily looking at caregiver HRQL, it is unclear which factors, measures, or subscales are most predictive of short- and/or long-term treatment outcomes for which type of patient, and which time points for measurement are most informative. A standardised protocol that incorporates HRQL and other relevant patient-related outcome measures and agreed definitions of outcomes would allow for the comparison of efficacy of food allergy treatments between centres, trials, or countries. Further evidence-based research aimed at exploring the effects of interventions on outcomes in food allergy is needed, including the influence of patient and parent factors on protocol design. To this end, it is vital that patient-related outcomes such as improved HRQL are seen as a primary outcome and are measured at multiple intervals during the trial duration and beyond. The creative use of methods and designs (both qualitative and quantitative) to better understand the role of HRQL in immunotherapy treatment trials will enable improved modelling of the costs, risks, and benefits of any treatment. Systematic analysis and modelling of antecedent factors, mediators, and outcomes will be important to boost intervention effects and to maximise the overall benefits of treatment.

Keywords

Psychosocial Mediators of change Patient selection factors Oral immunotherapy trials 

Notes

Compliance with Ethical Standards

Conflicts of Interest

I am an advisory consultant for Aimmune Therapeutics Biotechnology Company

aimmune.com

Headquarters: Brisbane, CA, USA

Ethical Approval and Informed Consent

All studies cited have obtained ethical approval and participants provided informed consent. The names of any participants and/or identifying information are not included in the manuscript.

References

  1. 1.
    Prescott S, Allen KJ (2011) Food allergy: riding the second wave of the allergy epidemic. Pediatr Allergy Immunol 22:155–160CrossRefGoogle Scholar
  2. 2.
    Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M, Fiocchi A, Chiang W, Beyer K, Wood R, Hourihane J, Jones SM, Lack G, Sampson HA (2012) ICON: food allergy. J Allergy Clin Immunol 129:906–920CrossRefGoogle Scholar
  3. 3.
    Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, Holl JL (2011) The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics 128:e9–e17CrossRefGoogle Scholar
  4. 4.
    Liew WK, Williamson E, Tang ML (2009) Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol 123:434–442CrossRefGoogle Scholar
  5. 5.
    Mullins RJ, Dear KB, Tang ML (2015) Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. J Allergy Clin Immunol 136:367–375CrossRefGoogle Scholar
  6. 6.
    Turner PJ, Gowland MH, Sharma V, Ierodiakonou D, Harper N, Garcez T, Pumphrey R, Boyle RJ (2015) Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992-2012. J Allergy Clin Immunol 135(4):956–963CrossRefPubMedCentralGoogle Scholar
  7. 7.
    Branum AM, Lukacs SL (2009) Food allergy among children in the United States. Pediatrics 124:1549–1555CrossRefGoogle Scholar
  8. 8.
    Sicherer SH, Forman JA, Noone SA (2000) Use assessment of self-administered epinephrine among food-allergic children and pediatricians. Pediatrics 105:359–362CrossRefGoogle Scholar
  9. 9.
    de Silva IL, Mehr SS, Tey D, Tang ML (2008) Paediatric anaphylaxis: a 5 year retrospective review. Allergy 63:1071–1076CrossRefGoogle Scholar
  10. 10.
    Umasunthar T, Leonardi-Bee J, Hodes M, Turner PJ, Gore C, Habibi P, Warner JO, Boyle RJ (2013) Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis. Clin Exp Allergy 43:1333–1341CrossRefPubMedCentralGoogle Scholar
  11. 11.
    Wassenberg J, Cochard MM, Dunngalvin A, Ballabeni P, Flokstra-de Blok BM, Newman CJ et al (2012) Parent perceived quality of life is age-dependent in children with food allergy. Pediatr Allergy Immunol 23:412–419CrossRefGoogle Scholar
  12. 12.
    Grabenhenrich L, Hompes S, Gough H, Ruëff F, Scherer K, Pföhler C, Treudler R, Mahler V, Hawranek T, Nemat K, Koehli A, Keil T, Worm M (2012) Implementation of anaphylaxis management guidelines: a register-based study. PLoS One 7:e35778CrossRefPubMedCentralGoogle Scholar
  13. 13.
    Dunn Galvin A, Hourihane JOB (2016) Health-related quality of life in food allergy: Impact, correlates, and predictors. Bundesgesundheitsbl © Springer-Verlag, Berlin HeidelbergGoogle Scholar
  14. 14.
    Varni J, Burwinkle T, Lane M (2005) Health-related quality of life measurement in pediatric clinical practice: an appraisal and precept for future research and application. Health Qual Life Outcomes 3:34CrossRefPubMedCentralGoogle Scholar
  15. 15.
    Cummings AJ, Knibb RC, King RM, Lucas JS (2010) The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy 65(8):933–945CrossRefGoogle Scholar
  16. 16.
    King RM, Knibb RC, Hourihane JO (2009) Impact of peanut allergy on quality of life, stress and anxiety in the family. Allergy 64:461–468CrossRefGoogle Scholar
  17. 17.
    Lyons AC, Forde EM (2004) Food allergy in young adults: perceptions and psychological effects. J Health Psychol 9:497–504CrossRefGoogle Scholar
  18. 18.
    Sicherer SH, Noone SA, Munoz-Furlong A (2001) The impact of childhood food allergy on quality of life. Ann Allergy Asthma Immunol 87:461–464CrossRefGoogle Scholar
  19. 19.
    Acquadro C, Berzon R, Dubois D, Leidy NK, Marquis P, Revicki D, Rothman M, PRO Harmonization Group (2003) Incorporating the patient’s perspective into drug development and communication: an ad hoc task force report on the patient-reported outcomes (PRO) harmonization group meeting at the Food and Drug Administration, February 16, 2001. Value Health 5:522–531CrossRefGoogle Scholar
  20. 20.
    Burke LB, Kennedy DL, Miskala PH, Papadopoulos EJ, Trentacosti AM (2008) The use of patient-reported outcome measures in the evaluation of medical products for regulatory approval. Clin Pharmacol Ther 84:281–283.  https://doi.org/10.1038/clpt.2008.128 CrossRefPubMedGoogle Scholar
  21. 21.
    The Six Domains of Health Care Quality. Content last reviewed. October 2017. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/quality-patient safety/talkingquality/create/sixdomains.html
  22. 22.
    Patrick DL, Burke LB, Powers JH, Scott JA, Rock EP, Dawisha S, O’Neill R, Kennedy DL (2007) Patient-reported outcomes to support medical product labeling claims: FDA perspective. Value Health 10(Suppl 2):S125–S137CrossRefGoogle Scholar
  23. 23.
    US Department of Health and Human Services, US Food and Drug Administration (2009) Guidance for industry: patient-reported outcome measures. use in medical product development to support labeling claims. US Food and Drug Administration, Washington, DCGoogle Scholar
  24. 24.
    European Medicines Agency, Committee for Medicinal Products for Human Use (CMHP) (2005) Reflection paper on the regulatory guidance for the use of Health-Related Quality of Life (HRQL) measures in the evaluation of medicinal products. European Medicines Agency, LondonGoogle Scholar
  25. 25.
    Flokstra-de Blok BMJ, Dubois AEJ, Vlieg-Boerstra BJ, Oude Elberink JNG, Raat H, DunnGalvin A, Hourihane JOB, Duiverman EJ (2010) Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy 65:238–244CrossRefGoogle Scholar
  26. 26.
    Goossens NJ, Flokstra-de Blok BM, van der Meulen GN, Arnlind MH, Asero R, Barreales L et al (2014) Health-related quality of life in food-allergic adults from eight European countries. Ann Allergy Asthma Immunol 113(63–8):e1Google Scholar
  27. 27.
    Dunn Galvin A et al (2016) An examination of the Food Allergy Quality of Life Questionnaire performance in a countrywide American sample of children: cross-cultural differences in age and impact in the United States and Europe. J Allergy Clin Immunol Pract 5(2):363–368.e2CrossRefGoogle Scholar
  28. 28.
    Flokstra-de Blok BM, Dubois AE (2012) Quality of life measures for food allergy. Clin Exp Allergy 42:1014–1020CrossRefGoogle Scholar
  29. 29.
    Flokstra-de Blok BM, Dubois AE (2009) Quality of life in food allergy: valid scales for children and adults. Curr Opin Allergy Clin Immunol 9:214–221CrossRefGoogle Scholar
  30. 30.
    Flokstra-de Blok BM, Dunn Galvin A, Vlieg-Boerstra BJ, Oude Elberink JN, Duiverman EJ, Hourihane JO et al (2009) Development and validation of a self-administered Food Allergy Quality of Life Questionnaire for children. Clin Exp Allergy 39:127–137CrossRefGoogle Scholar
  31. 31.
    Flokstra-de Blok BM, Dunn Galvin A, Vlieg-Boerstra BJ, Oude Elberink JN, Duiverman EJ, Hourihane JO et al (2008) Development and validation of the self-administered Food Allergy Quality of Life Questionnaire for adolescents. J Allergy Clin Immunol 122:139–144CrossRefGoogle Scholar
  32. 32.
    Flokstra-de Blok BM, van der Meulen GN, Dunn Galvin A, Vlieg-Boerstra BJ, Oude Elberink JN, Duiverman EJ et al (2009) Development and validation of the Food Allergy Quality of Life Questionnaire - adult form. Allergy 64:1209–1217CrossRefGoogle Scholar
  33. 33.
    Dunn Galvin A, Flokstra de Blok BM, Burks AW, Dubois AE, Hourihane JO (2008) Food allergy QoL questionnaire for children aged 0-12 years: content, construct, and cross-cultural validity. Clin Exp Allergy 38:977–986CrossRefGoogle Scholar
  34. 34.
    Dunn Galvin A, Cullinane C, Daly D, Flokstra-de Blok B, Dubois A, Hourihane J (2010) Longitudinal validity and responsiveness of the Food Allergy Quality of Life Questionnaire–Parent Form in children 0–12 years following positive and negative food challenges. Clin Exp Allergy 40:476–485CrossRefGoogle Scholar
  35. 35.
    van der Velde JL, Flokstra-de Blok BM, Vlieg-Boerstra BJ, Oude Elberink JN, Schouten JP, Dunngalvin A et al (2009) Testretest reliability of the Food Allergy Quality of Life Questionnaires (FAQLQ) for children, adolescents and adults. Qual Life Res 18:245–251CrossRefGoogle Scholar
  36. 36.
    Ferrans CA, Zerwic JJ, Wilbur JE, Larson JL (2005) Conceptual model of health-related quality of life. J Nurs Scholarsh 37:336–342CrossRefGoogle Scholar
  37. 37.
    Flokstra-de Blok BMJ (2014) Food Allergy Quality of Life Questionnaires (FAQLQ) Encyclopedia of quality of life and well-being research. Springer, p 2319–322Google Scholar
  38. 38.
    Buchanan AD, Green TD, Jones SM, Scurlock AM, Christie L, Althage KA et al (2007) Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 119:199–205CrossRefGoogle Scholar
  39. 39.
    Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler W et al (2011) Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol 127:640–646CrossRefPubMedCentralGoogle Scholar
  40. 40.
    Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S, Steele P, Driggers S, Burks AW, Wood RA (2012) The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 129:448–455CrossRefGoogle Scholar
  41. 41.
    Anagnostou K, Islam S, King Y, Foley L, Pasea L, Bond S, Palmer C, Deighton J, Ewan P, Clark A (2014) Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 383:1297–1304CrossRefPubMedCentralGoogle Scholar
  42. 42.
    Anagnostou K, Clark A (2014) Peanut immunotherapy. Clin Transl Allergy 4:30CrossRefPubMedCentralGoogle Scholar
  43. 43.
    Dupont C, Kalach N, Soulaines P, Legoue-Morillon S, Piloquet H, Benhamou PH (2010) Cow’s milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol 125:1165–1167CrossRefGoogle Scholar
  44. 44.
    Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT (2011) Rapid oral desensitization in combination with omalizumab therapy in patients with cow’s milk allergy. J Allergy Clin Immunol 127:1622–1624CrossRefPubMedCentralGoogle Scholar
  45. 45.
    Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O’Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos AF, van Ree R, Timmermans F, Sheikh A (2017) Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy 72:1133–1147CrossRefGoogle Scholar
  46. 46.
    Chin SJ, Vickery BP, Kulis MD, Kim EH, Varshney P, Steele P, Kamilaris J, Hiegel AM, Carlisle SK, Smith PB, Scurlock AM, Jones SM, Burks AW (2013) Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison. J Allergy Clin Immunol 132:476–478CrossRefPubMedCentralGoogle Scholar
  47. 47.
    Agbotounoi W, Martin L, Dupont D, Pascal I, Vauleon C, Benhamou PH (2012) Epicutaneous immunotherapy (EPIT) is safe for the treatment of peanut allergy in allergic patients [abstract]. J Allergy Clin Immunol 131(2 Suppl):AB91Google Scholar
  48. 48.
    Hofmann AM, Scurlock AM, Jones SM, Palmer KP, Lokhnygina Y, Steele PH, Kamilaris J, Burks AW (2009) Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 124:286–291CrossRefPubMedCentralGoogle Scholar
  49. 49.
    Muraro A, Dubois AE, Dunn Galvin A et al (2014) EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures. Allergy 69:845–853CrossRefGoogle Scholar
  50. 50.
    Avery NJ, King RM, Knight S, Hourihane JO (2003) Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol 14:378–382CrossRefGoogle Scholar
  51. 51.
    Polloni L, Baldi I, Lazzarotto F, Bonaguro R, Toniolo A, Gregori D, Muraro A (2015) Multidimensional analysis of food-allergic children and adolescents’ self-concept: a comparison with a healthy matched sample. J Health Psychol 20(6):850–857CrossRefGoogle Scholar
  52. 52.
    Dunn Galvin A, Gaffney A, Hourihane JO’B (2009) Developmental pathways in food allergy: a new theoretical model. Allergy 64:560–568CrossRefGoogle Scholar
  53. 53.
    Dunn Galvin A, Polloni L, Le Bovidge J, Muraro A, Greenhawt M, Taylor S, Burks W, Allen K, Sheikh A, Hourihane J, Tang M Development of the Food Allergy Coping and Experience Model (FACE): secondary analysis of data on IgE-mediated food allergy in children, young people and their parents from five countries. (JACI-P, accepted)Google Scholar
  54. 54.
    DunnGalvin et al (2009) Profiling families enrolled in immunotherapy studies. Pediatrics 142(3):e503–e509CrossRefGoogle Scholar
  55. 55.
    Wang J, Liu AH (2011) Food allergies and asthma. Curr Opin Allergy Clin Immunol 11(3):249–254CrossRefPubMedCentralGoogle Scholar
  56. 56.
    Klinnert MD, Silveira L, Harris R, Moore W, Atkins D, Fleischer DM, Menard-Katcher C, Aceves S, Spergel JM, Franciosi JP, Furuta GT (2014) Health related quality of life over time in children with eosinophilic esophagitis (EoE) and their families. J Pediatr Gastroenterol Nutr 59(3):308–316CrossRefPubMedCentralGoogle Scholar
  57. 57.
    Cortina S, McGraw K, de Alarcon A et al (2010) Psychological functioning of children and adolescents with eosinophil-associated gastrointestinal disorders. Child Health Care 39:266–278CrossRefPubMedCentralGoogle Scholar
  58. 58.
    Klinnert MD, Moore W, Miller J et al (2011) Impact of eosinophilic esophagitis on quality of life for youth and their families. J Allergy Clin Immunol 127(S):AB110Google Scholar
  59. 59.
    Mukkada V, Haas A, Creskoff Maune N et al (2010) Feeding dysfunction in children with eosinophilic gastrointestinal diseases. Pediatrics 126:e1–e7CrossRefGoogle Scholar
  60. 60.
    Ingerski L, Modi A, Hood K et al (2010) Health-related quality of life across pediatric chronic conditions. J Pediatr 156:639–644CrossRefPubMedCentralGoogle Scholar
  61. 61.
    Harris RF, Menard-Katcher C, Atkins D, Furuta GT, Klinnert MD (2013) Psychosocial dysfunction in children and adolescents with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 57:500–505CrossRefGoogle Scholar
  62. 62.
    Dunn Galvin A, Barnett J, Begen FM, Ryan K, Lucas JS (2017) Development and preliminary validation of the Food Intolerance Quality of Life Questionnaire (FIQLQ): adult form. Qual Life Res 27(4):1109–1116.  https://doi.org/10.1007/s11136-017-1732-0 CrossRefGoogle Scholar
  63. 63.
    Dunn Galvin A PAAM 2017 Symposium. Maternal Anxiety & Food avoidanceGoogle Scholar
  64. 64.
    DunnGalvin et al (2016) An examination of the Food Allergy Quality of Life Questionnaire performance in a countrywide American sample of children: cross-cultural differences in age and impact in the United States and Europe. J Allergy Clin Immunol Pract 5(2):363–368.  https://doi.org/10.1016/j.jaip.2016.09.049 PubMedGoogle Scholar
  65. 65.
    McHenry, Watson (2014) Impact of primary food allergies on the introduction of other foods amongst Canadian children and their siblings. Allergy, Asthma Clin Immunol 10(1):26CrossRefGoogle Scholar
  66. 66.
    Barnett J, Muncer K, Leftwich J, Shepherd R, Raats MM, Gowland MH, Grimshaw K, Lucas JS (2011) Using ‘may contain’ labelling to inform food choice: a qualitative study of nut allergic consumers. BMC Public Health 11:734CrossRefPubMedCentralGoogle Scholar
  67. 67.
    Beyer K, Eckermann O, Hompes S, Grabenhenrich L, Worm M (2012) Anaphylaxis in an emergency setting - elicitors, therapy and incidence of severe allergic reactions. Allergy 67:1451–1456CrossRefGoogle Scholar
  68. 68.
    Kelleher MM, Hourihane JO’B, Dunngalvin A, Cullinane C, Fitzsimons J, Sheikh A (2012) A 24-h helpline for access to expert management advice for food allergy-related anaphylaxis in children: protocol for a pragmatic randomised controlled trial. BMJ 131(2 Suppl):AB219Google Scholar
  69. 69.
    Calsbeek H, Rijken M, Dekker J, van Berge Henegouwen GP (2006) Disease characteristics as determinants of the labour market position of adolescents and young adults with chronic digestive disorders. Eur J Gastroenterol Hepatol 18:203–209CrossRefGoogle Scholar
  70. 70.
    Shemesh E, Annunziato RA, Ambrose MA, Ravid NL, Mullarkey C, Rubes M, Chuang K, Sicherer M, Sicherer SH (2013) Child and parental reports of bullying in a consecutive sample of children with food allergy. Pediatrics 131:e10–e17.  https://doi.org/10.1542/peds.2012-1180 CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Dunn Galvin A (2017) The experience of eating out on the Island of Ireland in 2013 prior to and following introduction of the ‘Food Information for Consumers Regulation’. Safe Food ReportGoogle Scholar
  72. 72.
    Dunn Galvin A, Roberts G et al Understanding how consumers with allergies make decisions based on precautionary labelling. SubmittedGoogle Scholar
  73. 73.
    Compas BE, Jaser SS, Dunn MJ, Rodriguez EM (2012) Coping with chronic illness in childhood and adolescence. Annu Rev Clin Psychol 8:455–480CrossRefGoogle Scholar
  74. 74.
    Greenhawt M, Dunn Galvin A Preliminary psychometric analyses and clinical performance of a caregiver self-efficacy scale for food allergy self-management. Ann Allergy Asthma Immunol (in press)Google Scholar
  75. 75.
    Baxter P, Jack S (2008) Qualitative case study methodology: study design and implementation for novice researchers. Qual Rep 13(4):544–559Google Scholar
  76. 76.
    DunnGalvin et al Preliminary Development of the Food Allergy Coping and Emotions (FACE) questionnaires for children, adolescents and young people: qualitative analysis of data on IgE-mediated food allergy from five countries. (JAIP, accepted)Google Scholar
  77. 77.
    World Health Organisation. Innovative Care for Chronic Conditions: Building Blocks for Action http://www.who.int/chp/knowledge/publications/icccreport/en/ Accessed. October 2017
  78. 78.
    Bandura A (1977) Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev 84:191–215CrossRefGoogle Scholar
  79. 79.
    Tamagawa R, Garland S, Vaska M, Carlson LE (2012) Who benefits from psychosocial interventions in oncology? A systematic review of psychological moderators of treatment outcome. J Behav Med 35(6):658–673CrossRefGoogle Scholar
  80. 80.
    Ferro MA, Van Lieshout RJ, Ohayon J, Scott JG (2015) Emotional and behavioral problems in adolescents and young adults with food allergy. Allergy 71(4):532–540.   https://doi.org/10.1111/all.12829 CrossRefGoogle Scholar
  81. 81.
    Sifneos PE (1973) The prevalence of “alexithymic” characteristics in psychosomatic patients. Psychother Psychosom 22:255–262CrossRefGoogle Scholar
  82. 82.
    Baiardini I, Abbà S, Ballauri M, Vuillermoz G, Braido F (2011) Alexithymia and chronic diseases: the state of the art. G Ital Med Lav Ergon 33(1 Suppl A):A47–A52PubMedGoogle Scholar
  83. 83.
    Polloni L, Ferruzza E, Ronconi L, Lazzarotto F, Bonaguro R, Toniolo A, Celegato N, Muraro A (2015) Mental health and behavior of food-allergic adolescents compared to a healthy matched sample. Ann Allergy Asthma Immunol 115(2):158–160CrossRefGoogle Scholar
  84. 84.
    Lumley MA, Stettner L, Wehmer F (1996) How are alexithymia and physical illness linked? A review and critique of pathways. J Psychosom Res 41:505–518CrossRefGoogle Scholar
  85. 85.
    Kano M, Fukudo S (2013) The alexithymic brain: the neural pathways linking alexithymia to physical disorders. Biopsychosoc Med 7:1CrossRefPubMedCentralGoogle Scholar
  86. 86.
    Bruni R, Serino FM, Galluzzo S, Coppolino G, Cacciapaglia F, Vadacca M et al (2006) Alexithymia and neuroendocrine-immune response in patients with autoimmune diseases: preliminary results on relationship between alexithymic construct and TNF-α levels. Ann N Y Acad Sci 1069:208–211CrossRefGoogle Scholar
  87. 87.
    Guilbaud O, Curt F, Perrin C, Chaouat G, Berthoz S, Dugré-Le Bigre C et al (2009) Decreased immune response in alexithymic women: a cross-sectional study. Biomed Pharmacother 63:297–304CrossRefGoogle Scholar
  88. 88.
    Guilbaud O, Corcos M, Hjalmarsson L, Loas G, Jeammet P (2003) Is there a psychoneuroimmunological pathway between alexithymia and immunity? Immune and physiological correlates of alexithymia. Biomed Pharmacother 57:292–295CrossRefGoogle Scholar
  89. 89.
    Knibb RC, Horton SL (2008) Can illness perceptions and coping predict psychological distress amongst allergy sufferers? Br J Health Psychol 13(Pt 1):103–119CrossRefGoogle Scholar
  90. 90.
    Polloni L, Dunn Galvin A, Ferruzza E, Bonaguro R, Lazzarotto F, Toniolo A, Celegato N, Muraro A (2017) Coping strategies, alexithymia and anxiety in young patients with food allergy. Allergy 72:1054–1060CrossRefGoogle Scholar
  91. 91.
    Wasserman RL, Sugerman R, Mireku-Akomeah L, Gallucci AR, Pence DM, Long NA (2011) Peanut oral immunotherapy (OIT) of food allergy (FA) carries a significant risk of eosinophilic esophagitis (EoE). JACI 127(Issue 2, Supplement):AB28Google Scholar
  92. 92.
    Greenhawt M Personal communication. (I have emailed for permission)Google Scholar
  93. 93.
    Otani M, Bégin P, Kearney C, Dominguez T, Mehrotra A, Bacal LR, Wilson SK (2013) Multi-allergen oral immunotherapy improves quality of life in subjects with food allergies. JACI 131(Issue 2, Supplement):AB58Google Scholar
  94. 94.
    Otani M, Bégin P, Kearney C, Dominguez T, Mehrotra A, Bacal LR, Wilson SK (2014) Multiple-allergen oral immunotherapy improves quality of life in caregivers of food- allergic pediatric subjects. JACI 10:25Google Scholar
  95. 95.
    Factor JM, Mendelson L, Lee J, Nouman G, Lester MR (2012) Effect of oral immunotherapy to peanut on food-specific quality of life. Ann Allergy Asthma Immunol 109(5):348–352.e2 08.015CrossRefGoogle Scholar
  96. 96.
    Tang MLK, Hsiao KC (2016) An update on oral immunotherapy for the treatment of food allergy. Paediatr Child Health 26:304–309CrossRefGoogle Scholar
  97. 97.
    Kuang-Chih H, Ponsonby AL, Axelrad C, Tang M (2017) Long term effects of a probiotic and peanut oral immunotherapy (PPOIT) treatment on peanut allergic children. J Allergy Clin Immunol 139(2 Suppl):AB136Google Scholar
  98. 98.
    Dunn Galvin A, McMahon, Ponsonby AL, Hsiao KC, Tang MLK (2017) The longitudinal impact of probiotic and peanut oral immunotherapy on health-related quality of life. Allergy 73(3):560–568.  https://doi.org/10.1111/all.13330 CrossRefGoogle Scholar
  99. 99.
    Gupta RS, Springston EE, Kim JS, Smith B, Pongracic JA, Wang X, Holl J (2010) Food allergy knowledge, attitudes, and beliefs of primary care physicians. Pediatrics 125:126–132CrossRefGoogle Scholar
  100. 100.
    Rabin R, de Charro F (2001) EQ-5D: a measure of health status from the EuroQol Group. Ann Med 33:337–343CrossRefGoogle Scholar
  101. 101.
    Macran S, Weatherly H, Kind P (2003) Measuring population health: a comparison of three generic health status measures. Med Care 41:218–231.11PubMedGoogle Scholar
  102. 102.
    Martin LR, Williams SL, Haskard KB, DiMatteo MR (2005) The challenge of patient adherence. Ther Clin Risk Manag 1(3):189–199PubMedPubMedCentralGoogle Scholar
  103. 103.
    McKenna SP, Ratcliffe J, Meads DM, Brazier JE (2008) Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses. Health Qual Life Outcomes 6:65CrossRefPubMedCentralGoogle Scholar
  104. 104.
    Doward LC, McKenna SP, Meads DM, Ratcliffe J, Whalley D, Langley PC (2002) Investigation into the feasibility of deriving relative and absolute utility from the Recurrent Genital Herpes Quality of Life Questionnaire (RGHQoL). Value Health 5:573–574CrossRefGoogle Scholar

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Authors and Affiliations

  1. 1.School of Applied PsychologyUniversity College CorkCork CityIreland
  2. 2.Department of Paediatrics & Child HealthUniversity College CorkCorkIreland

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