Clinical Reviews in Allergy & Immunology

, Volume 55, Issue 1, pp 7–18 | Cite as

Eosinophilic Esophagitis Clinical Manifestations and Differential Diagnosis

  • Diana Muñoz-Mendoza
  • Adrián Chapa-Rodríguez
  • Sami L. BahnaEmail author


As a chronic inflammatory disease with eosinophilic infiltrate of the esophagus, eosinophilic esophagitis (EoE) causes a variety of gastrointestinal (GI) clinical manifestations. None of the symptoms, endoscopic features, or biopsy findings is pathognomonic of the disease, even with high degrees of esophageal eosinophilia. The pathogenesis has been explored by several studies, yet it still far from being completely understood. Evidence supports a role of allergen-driven Th2 lymphocyte mechanism, though not in every patient. This article addresses the disease’s clinical manifestations, endoscopic findings, diagnosis, and differential diagnoses. In addition to the current diagnostic criteria, we summarize some recently emerging procedures that promise of enhancing more precise diagnosis and institution of early appropriate management, with consequent better quality of life and reduction of complications.


Eosinophilic esophagitis Eosinophilic diseases Gastrointestinal allergy Gastrointestinal disorders Food allergy 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

Not applicable; this is a review article.

Informed Consent

Not applicable; this is a review article.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Diana Muñoz-Mendoza
    • 1
  • Adrián Chapa-Rodríguez
    • 2
  • Sami L. Bahna
    • 1
    Email author
  1. 1.Department of Pediatrics, Allergy and Immunology SectionLouisiana State University Health Sciences Center in ShreveportShreveportUSA
  2. 2.Department of Pediatrics, Gastroenterology and Nutrition SectionLouisiana State University Health Sciences Center in ShreveportShreveportUSA

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