Clinical Reviews in Allergy & Immunology

, Volume 57, Issue 1, pp 39–54 | Cite as

A Comprehensive Review on Mustard-Induced Allergy and Implications for Human Health

  • Akanksha Sharma
  • Alok K. Verma
  • Rinkesh Kumar Gupta
  • Neelabh
  • Premendra D. DwivediEmail author


Mustard is widely used in a variety of foods/food products to enhance the flavor and nutritional value that subsequently raise the risk of hypersensitivity reactions. Mustard allergy has been reported for many years and is increasing gradually especially in the areas where its consumption is comparatively higher, and it may be considered among the most important food allergies. A number of relevant clinical studies focused on mustard-induced allergic manifestations are summarized in the current review. In addition, the knowledge regarding the immunological as well as biochemical characteristics of mustard allergens that have been known till date and their cross-reactivity with other food allergens have also been discussed here. Notably, mustard may also be present as a hidden allergen in foods; therefore, it is important to recognize food products that may contain mustard as it may pose potential risk for the allergic individuals. Additionally, the better understanding of the underlying mechanism in mustard allergy is a prerequisite for the development of specific therapeutic procedures. Conclusively, mustard sensitivity should be routinely tested in patients with idiopathic anaphylaxis for the safety of the allergic patients.


Mustard allergy Cross-reactivity Hidden allergen Anaphylaxis 



Antigen-presenting cells


Skin prick test


Double-blind placebo-controlled food challenge


Pollen-food allergy syndrome


Latex allergy


Natural rubber latex


Monoclonal antibodies


Lipid transfer proteins


Molecular weight



The authors wish to thank Professor Alok Dhawan, Director, CSIR-IITR for his encouragement and support. Financial support from CSIR Research Grant InDepth (BSC-0111) is acknowledged. Dr. Akanksha Sharma is grateful to the Council of Scientific and Industrial Research, New Delhi, for the award of her Senior Research Fellowship. She conveys her gratitude to the Academy of Scientific and Innovative Research (AcSIR), New Delhi. Mr. Rinkesh Kumar Gupta and Neelabh are thankful to the Indian Council of Medical Research (ICMR), New Delhi, for the award of their Senior Research Fellowship. This is CSIR-IITR manuscript no-3481.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Akanksha Sharma
    • 1
    • 3
  • Alok K. Verma
    • 2
  • Rinkesh Kumar Gupta
    • 1
  • Neelabh
    • 4
  • Premendra D. Dwivedi
    • 1
    • 3
    Email author
  1. 1.Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR)LucknowIndia
  2. 2.Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders CenterTulane University School of MedicineNew OrleansUSA
  3. 3.Academy of Scientific and Innovative Research (AcSIR)LucknowIndia
  4. 4.Department of ZoologyBanaras Hindu University (BHU)Varanasi, Uttar PradeshIndia

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