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Stem Cell Reviews and Reports

, Volume 15, Issue 5, pp 652–663 | Cite as

Biological Characteristics and Regulation of Early Megakaryocytopoiesis

  • Jingang Yang
  • Song Zhao
  • Dongchu MaEmail author
Article

Abstract

For decades, megakaryocytopoiesis is believed to occur following a classical binary hierarchical developmental model. This model is based on an analysis of predefined flow-sorted cell populations by using cell surface markers. However, this classical model has been challenged by increasing evidences obtained with new techniques which integrating flow cytometric, transcriptomic and functional data at single-cell level and with lineage tracing technique. These recent advances in megakaryocytopoiesis proposed that commitment of haematopoietic stem cells (HSCs) towards megakaryocytic lineage occurs in much earlier stage than that postulated in the classical model. There may exist multipotent but megakaryocyte (MK)/platelet-biased HSCs within HSC compartment and even HSCs can directly differentiate into MKs in steady state or in response to stress. In this review, we focus on recent findings about differentiation from commitment of HSCs to MK and its regulation, and discuss future directions in this research field.

Keywords

Binary hierarchical developmental model Megakaryocytopoiesis Haematopoietic stem cells Commitment 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 31571398).

Compliance with Ethical Standards

Disclosures

The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. 1.Department of Experimental MedicineGeneral Hospital of Northern Theatre CommandShenyangPeople’s Republic of China

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