Evolving Definition of Adult Stem/Progenitor Cells
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Adult stem cells (ASCs) comprise a rare population of cells that are expected to be (i) quiescent (ii) undergo asymmetric cell divisions (ACD) to self-renew and give rise to tissue committed ‘progenitors’ and (iii) exhibit ‘plasticity’ implying the ability to differentiate into different lineages. Unlike embryonic stem cells which are ‘immortal’, can differentiate into 200 odd cell types and are defined by their origin (inner cell mass of the blastocyst), ASCs share no such definitive means of characterization, are set aside during development, are lineage restricted and are restrained from proliferation/differentiation by their tissue-specific niche/microenvironment. Clonal expansion is another property of stem cells which implies that they can give rise to a sphere of cells by rapid proliferation and incomplete cytokinesis resulting in the formation of spheres like mammosphere, neurosphere, cardiosphere etc. As a result, two distinct populations comprising quiescent and actively...
Contributions of all working in the field is acknowledged.
Author acknowledges financial support from Indian Council of Medical Research Government of India, New Delhi, INDIA.
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Conflict of Interest
Authors declare no conflicts of interest.
- 11.Bhartiya, D. Clinical translation of stem cells for regenerative medicine- a comprehensive analysis. Accepted in Circulation Research. https://doi.org/10.1161/CIRCRESAHA.118.313823.