Stem Cell Reviews and Reports

, Volume 15, Issue 1, pp 23–34 | Cite as

Integrative Analysis of CD133 mRNA in Human Cancers Based on Data Mining

  • Gui-Min Wen
  • Fei-Fei Mou
  • Wei Hou
  • Dan Wang
  • Pu XiaEmail author


CD133 is a wildly used cancer stem cell marker. The purpose of this study was to explore the significance of CD133 mRNA in human cancers mainly based on The Cancer Genome Atlas (TCGA) database. Bioinformatic analyses were done by using public repositories, including BioGPS, SAGE Genie tools, Oncomine analysis, Regulome Explorer, COSMIC analysis, and Kaplan-Meier Plotter. The main findings in this study were: 1) High CD133 mRNA was correlated with a benign survival rate of gastric cancer and lung cancer; 2) Transmembrane protein 125 (TMEM125) in bladder urothelial carcinoma and intercellular adhesion molecule 2 (ICAM2) in ovarian serous cystadenocarcinoma were closely related to CD133 expression; 3) The location and the topological structure of CD133 protein were not determined by its transcript variant in cancer cells; 4) CD38 and CD200 may be used as novel surface markers for solid cancers. However, the mechanism of these findings is not completely clear, further studies have to be performed in the future.


CD133 TCGA Cancer Bioinformatic analyses Mechanism 



This study was supported by National Natural Scientific Foundation of China (No.81502558) and Talents Introduction Projects of Liaoning Medical University.

Compliance with Ethical Standards

Conflict of Interest


Supplementary material

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Authors and Affiliations

  1. 1.Department of Basic Nursing, College of NursingLiaoning Medical UniversityJinzhouPeople’s Republic of China
  2. 2.Shijiazhuang Medical CollegeShijiazhuangPeople’s Republic of China
  3. 3.Department of Medical Genetics, College of Basic Medical ScienceLiaoning Medical UniversityJinzhouPeople’s Republic of China
  4. 4.Department of Histology and Embryology, College of Basic Medical ScienceLiaoning Medical UniversityJinzhouPeople’s Republic of China
  5. 5.Department of Cell Biology, College of Basic Medical Science, and Biological Anthropology InstituteLiaoning Medical UniversityJinzhouPeople’s Republic of China

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