Stem Cell Reviews and Reports

, Volume 15, Issue 2, pp 176–193 | Cite as

Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story

  • Gabrielle Mangin
  • Nathalie KubisEmail author


Stroke is a major public health issue with limited treatment. The pharmacologically or mechanically removing of the clot is accessible to less than 10% of the patients. Stem cell therapy is a promising alternative strategy since it increases the therapeutic time window but many issues remain unsolved. To avoid a new dramatic failure when translating experimental data on the bedside, this review aims to highlight the indispensable checkpoints to make a successful clinical trial based on the current preclinical literature. The large panel of progenitors/ stem cells at the researcher’s disposal is to be used wisely, regarding the type of cells, the source of cells, the route of delivery, the time window, since it will directly affect the outcome. Mechanisms are still incompletely understood, although recent studies have focused on the inflammation modulation of most cells types.


Stem cells Progenitors Brain ischemia Cerebrovascular disease Immunomodulation 



adipose mesenchymal stem cell


blood brain barrier


bone marrow


cord blood


endothelial colony forming cell


endothelial progenitor cell


embryonic stem cell


human umbilical cord blood


hematopoietic stem cell






induced pluripotent stem cell




myeloid angiogenic cell


multipotent adult progenitor cell




mesenchymal stem cell


mononuclear cells


neural progenitor cell


neural stem cell


peripheral blood


permanent middle cerebral artery occlusion


smooth muscle progenitor cell


subventricular zone


transient middle cerebral artery occlusion



GM was funded by the RESSTORE project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 681044 RESSTORE project ( The authors wish to thank the site for their image bank, which was used in part for the graphical illustration.

Compliance with Ethical Standards

Conflict of Interests

The authors have declared that no competing interest exists.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.INSERM U965ParisFrance
  2. 2.Sorbonne Paris CitéUniversité Paris DiderotParisFrance
  3. 3.Service de Physiologie Clinique-Explorations Fonctionnelles, AP-HPHôpital LariboisièreParisFrance

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