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Cadmium Exposure and Blood Telomere Length in Female University Students in Japan

  • Yuki Mizuno
  • Shoko Konishi
  • Hideki Imai
  • Eiji Fujimori
  • Nobuhiko Kojima
  • Jun YoshinagaEmail author
Article

Abstract

Cadmium is a toxic metal found ubiquitously throughout the world. Our study evaluated whether cadmium exposure was associated with telomere length in 73 female university students. Determination of telomere length was performed by quantitative polymerase chain reaction using DNA in blood. Urinary cadmium concentration was measured by inductively coupled plasma mass spectrometry. The students’ physiological attributes and lifestyle were surveyed by means of a self-administered questionnaire. The geometric mean of urinary cadmium concentration was 0.312 μg/g creatinine, which was lower than the levels previously reported for Japan. Urinary cadmium concentration was not significantly associated with telomere length, though the exposure level of the present subjects was similar to that of previous study subjects which found significantly negative associations. It is possible that other factors affected telomere length in this study population.

Keywords

Cadmium Female university student Japan Blood telomere length 

Abbreviations

BMI

Body mass index

ICP-MS

Inductively coupled plasma mass spectrometry

PCR

Polymerase chain reaction

T/S ratio

Telomere/single copy gene ratio

Notes

Acknowledgements

We thank the subjects of this study for their cooperation, and Ms. Yoko Nakamura, Faculty of Life Sciences, Toyo University, for helping with the preparation of the collection of samples.

Funding

This work was funded by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant number 16H05254).

Compliance with Ethical Standards

Conflict of Interest

Shoko Konishi and Jun Yoshinaga have received research grants from the Japan Society for the Promotion of Science.

Yuki Mizuno, Eiji Fujimori, Nobuhiko Kojima and Hideki Imai declare that they have no conflict of interest.

Ethical Approval

This study was approved by the Ethics Committee of Toyo University, Tokyo Healthcare University, and the Faculty of Medicine at the University of Tokyo in Japan.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

12011_2019_1656_MOESM1_ESM.docx (16 kb)
Table S1 (DOCX 15 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yuki Mizuno
    • 1
  • Shoko Konishi
    • 1
    • 2
  • Hideki Imai
    • 3
  • Eiji Fujimori
    • 4
  • Nobuhiko Kojima
    • 5
  • Jun Yoshinaga
    • 5
    Email author
  1. 1.Department of Human Ecology, School of International Health, Graduate School of MedicineUniversity of TokyoTokyoJapan
  2. 2.Department of AnthropologyUniversity of WashingtonSeattleUSA
  3. 3.Department of NursingTokyo Healthcare UniversityTokyoJapan
  4. 4.National Environmental Research and Training InstituteTokorozawa CityJapan
  5. 5.Faculty of Life SciencesToyo UniversityItakura, OraJapan

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