Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus
- 19 Downloads
Selenium (Se) is an essential micronutrient required by the human body and exerts biological functions through selenoproteins. The relationship between Se and diabetes remains ambiguous. This study aimed at, through measurements of serum selenoprotein P (SelP), glutathione peroxidase (GPx3), and Se content in serum and hair, evaluating Se levels in community dwellers with type 2 diabetes mellitus (T2DM). A total of 336 subjects, including 176 T2DM patients (65.5 ± 8.7 years old) and 160 healthy residents (63.7 ± 9.8 years old, as controls), were recruited in this cross-sectional community-based study performed in Suzhou. Samples of fasting venous blood and hair were collected for measurements of Se levels, glycometabolism, and biochemistry parameters. We found that the serum Se level and SelP concentration in T2DM patients were substantially higher than those in healthy residents (p < 0.05). There was no significant difference in GPx3 activity and hair Se level between the two groups of subjects (p > 0.05). Serum Se was positively correlated with both GPx3 and hair Se in T2DM patients (r = 0.167 and 0.164, respectively, p < 0.05) and negatively correlated with SelP in healthy controls (r = − 0.293, p < 0.05). In conclusion, this study showed significantly higher levels of serum Se and SelP in community dwellers with T2DM than in matched healthy residents.
KeywordsDiabetes mellitus, type 2 Selenium Selenoprotein P Glutathione peroxidase
We would like to thank all volunteers who participated in this study for their effort and time.
Authorship of All the Authors
Li Wang designed this study and wrote the final draft of the paper; Qianqian Zhang, Wenxia Li, Biyue Hu, and Hang Yun performed the experiments and analyzed the data; and Qianqian Zhang wrote the first draft of the paper. Jian Wang and Renmei Guo recruited volunteers and performed blood and hair sample selenium test. All authors critically reviewed the manuscript and approved the final version submitted for publication.
This work was funded by the Startup Foundation for Talents of Soochow University (Q412700114).
Compliance with Ethical Standards
All participants were fully informed about the research purpose and characteristics before they provided signed consent. Ethical approval was granted from the Ethics Committee of Soochow University (ECSU-201700044). This study conformed to the standards of the Declaration of Helsinki and was registered with Chinese Clinical Trial Registry (ChiCTR-IOR-17013645).
Conflict of Interest
The authors declare that they have no conflict of interest.
- 5.Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E (2009) Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environ Health Perspect 117(9):1409–1413. https://doi.org/10.1289/ehp.0900704 CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Othman FB, Mohamed HJBJ, Sirajudeen KNS, Noh MFBM, Rajab NF (2017) The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus: a case-control study. J Trace Elem Med Biol 43:106–112. https://doi.org/10.1016/j.jtemb.2016.12.009 CrossRefPubMedGoogle Scholar
- 13.Yang SJ, Hwang SY, Choi HY, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM (2011) Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. J Clin Endocrinol Metab 96(8):E1325–E1329. https://doi.org/10.1210/jc.2011-0620 CrossRefPubMedGoogle Scholar
- 14.Gonzalez de Vega R, Fernandez-Sanchez ML, Fernandez JC, Alvarez Menendez FV, Sanz-Medel A (2016) Selenium levels and glutathione peroxidase activity in the plasma of patients with type II diabetes mellitus. J Trace Elem Med Biol 37:44–49. https://doi.org/10.1016/j.jtemb.2016.06.007 CrossRefPubMedGoogle Scholar
- 15.Du RS, Yu YJ, Xiao WM (2017) Correlation between serum zinc, selenium, chromium, copper and blood glucose levels in type 2 diabetes patients. Int J Lab Med 38(8):1059–1063 (In Chinese)Google Scholar
- 17.Garcia-Fontana B, Morales-Santana S, Longobardo V, Reyes-Garcia R, Rozas-Moreno P, Garcia-Salcedo JA, Munoz-Torres M (2015) Relationship between proinflammatory and antioxidant proteins with the severity of cardiovascular disease in type 2 diabetes mellitus. Int J Mol Sci 16(5):9469–9483. https://doi.org/10.3390/ijms16059469 CrossRefPubMedPubMedCentralGoogle Scholar
- 21.Mei ZQ (1985) Two high selenium areas found in China. Chin J Endemiol 4(4):379–388 (In Chinese)Google Scholar
- 25.Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN (2011) Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal 14(12):2327–2336. https://doi.org/10.1089/ars.2010.3526 CrossRefPubMedPubMedCentralGoogle Scholar
- 26.Zeng MS, Li X, Liu Y, Zhao H, Zhou JC, Li K, Huang JQ, Sun LH, Tang JY, Xia XJ, Wang KN, Lei XG (2012) A high-selenium diet induces insulin resistance in gestating rats and their offspring. Free Radic Biol Med 52(8):1335–1342. https://doi.org/10.1016/j.freeradbiomed.2012.01.017 CrossRefPubMedPubMedCentralGoogle Scholar
- 34.Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S (2010) A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab 12(5):483–495. https://doi.org/10.1016/j.cmet.2010.09.015 CrossRefPubMedGoogle Scholar
- 36.Pan JM, Yu HY, Zhang L, Han JF, Bao YQ, Jia WP (2014) Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance. Natl Med J China 94(22):1710–1713 (In Chinese)Google Scholar
- 38.Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN (2012) High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal 16(3):185–192. https://doi.org/10.1089/ars.2011.3997 CrossRefPubMedPubMedCentralGoogle Scholar
- 42.Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, Channon KM (2002) Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P) H oxidase and endothelial nitric oxide synthase. Circulation 105(14):1656–1662. https://doi.org/10.1161/01.cir.0000012748.58444.08 CrossRefPubMedGoogle Scholar
- 43.Olson GE, Whitin JC, Hill KE, Winfrey VP, Motley AK, Austin LM, Deal J, Cohen HJ, Burk RF (2010) Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. Am J Physiol Renal Physiol 298(5):F1244–F1253. https://doi.org/10.1152/ajprenal.00662.2009 CrossRefPubMedGoogle Scholar
- 44.Yang Y, Wei W, Tai LX, Zhu GH, Niu CL (2008) Determination of trace element selenium in hair of patients with diabetes from Chuxiong district by 2,3-2-naphthylamine. Guangdong Trace Elements Sci 15(11):16–18 (In Chinese)Google Scholar