Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials

  • Maryam Khazdouz
  • Shirin Djalalinia
  • Sara Sarrafi Zadeh
  • Motahareh Hasani
  • Farzad Shidfar
  • Asal Ataie-Jafari
  • Hamid Asayesh
  • Maryam Zarei
  • Armita Mahdavi Gorabi
  • Mehdi Noroozi
  • Mostafa QorbaniEmail author


The prevalence of cardiometabolic risk factors has been increasing worldwide. The results of reported studies on the effects of zinc supplementation on cardiometabolic risk factors are unequivocal. This systematic review and meta-analysis of randomized controlled trials was conducted to evaluate the effects of zinc supplementation on cardiometabolic risk factors. A systematic search was conducted through international databases (PubMed/Medline, Institute of Scientific Information, and Scopus) until December 2018 to include all randomized controlled trials (RCT), quasi-RCT, and controlled clinical trials which assessed the effect of zinc supplementation on cardiometabolic risk factors including lipid profile, glycemic indices, blood pressure, and anthropometric indices. Random- or fixed-effects meta-analysis method was used to estimate the standardized mean difference (SMD) and 95% confidence interval (CI). A total of 20 studies were included in the meta-analysis, which included a total of 1141 participants in the intervention group. Meta-analysis showed that zinc supplementation significantly decreased plasma levels of triglyceride (SMD − 0.66, 95% CI − 1.27, − 0.06), very-low-density lipoprotein (SMD − 1.59, 95% CI − 2.86, − 0.31), and total cholesterol (SMD − 0.65, 95% CI − 1.15, − 0.15). Similarly, zinc supplementation significantly decreased fasting blood glucose (SMD − 0.52, 95% CI − 0.96, − 0.07) and HbA1c (SMD − 0.64, 95% CI − 1.27, − 0.02). The effects of zinc supplementation on blood pressure and anthropometric indices were not statistically significant (P > 0.05). Zinc supplements had beneficial effects on glycemic indices and lipid profile. Thus, it appeared that zinc supplementation might be associated with a decrease in cardiometabolic risk factors contributing to a reduction in risk of atherosclerosis.


Metabolic syndrome Cardiometabolic risk factors Zinc supplementation Meta-analysis Systematic review 



The authors are thankful to the Emam Ali Clinical Research Development Unit for the assistance.

Authors’ Contributions

MQ, MGH, MKH, and SD designed the research; SM and HA conducted the research; PT analyzed the data; MN, AA, and FS wrote the paper. All authors read and approved the final manuscript.

Funding information

This study was funded by Alborz University of Medical Sciences.

Compliance with Ethical Standards

The present study was approved by the ethical committee of Alborz University of Medical Sciences.

Competing Interests

The authors declare that they have no competing interests.

Supplementary material

12011_2019_1870_MOESM1_ESM.pdf (124 kb)
ESM 1 (PDF 124 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Maryam Khazdouz
    • 1
  • Shirin Djalalinia
    • 2
    • 3
  • Sara Sarrafi Zadeh
    • 4
  • Motahareh Hasani
    • 1
  • Farzad Shidfar
    • 1
  • Asal Ataie-Jafari
    • 4
  • Hamid Asayesh
    • 5
  • Maryam Zarei
    • 6
  • Armita Mahdavi Gorabi
    • 7
  • Mehdi Noroozi
    • 8
  • Mostafa Qorbani
    • 9
    • 10
    Email author
  1. 1.School of Public HealthIran University of Medical SciencesTehranIran
  2. 2.Development of Research & Technology Center, Deputy of Research and TechnologyMinistry of Health and Medical EducationTehranIran
  3. 3.Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Department of Nutrition, Science and Research BranchIslamic Azad UniversityTehranIran
  5. 5.Department of Medical EmergenciesQom University of Medical SciencesQomIran
  6. 6.Department of Nutrition and Dietetics, Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdangMalaysia
  7. 7.Department of Basic and Clinical Research, Tehran Heart CenterTehran University of Medical SciencesTehranIran
  8. 8.Social Determinants of Health Research CenterUniversity of Social Welfare and Rehabilitation SciencesTehranIran
  9. 9.Non-communicable Diseases Research CenterAlborz University of Medical SciencesKarajIran
  10. 10.Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran

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