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Investigations on Modulating Effect of Vanadium Supplementation on Growth and Metabolism Through Improved Immune Response, Antioxidative Profile and Endocrine Variables in Hariana heifers

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This study was conducted to investigate the effect of vanadium (V) supplementation on growth, metabolism, antioxidant, and immunological and endocrine variables in Hariana heifers. Eighteen indigenous Hariana heifers (body weight 130.0 ± 3.0 kg; age 10.0 ± 2.0 months) were randomly blocked into three groups, each comprising of six animals. All the animals were on same dietary plan except that the respective groups were additionally supplemented with 0.0, 2.5, and 5.0 mg of V/kg dry matter (DM), during the experimental period of 90 days. There was a linear increase (p < 0.05) in mean DMI and ADG in 5.0 mg of V/kg DM-supplemented group. However, the feed efficiency remained unaffected. Although no effects (p > 0.05) of V supplementation were observed on hemato-biochemical attributes, the mean plasma V concentration showed dose-dependent increase (p < 0.001) on V supplementation. The activity of SOD was significantly higher (p < 0.001), whereas mean values of LPO decreased linearly (p < 0.05) in V-supplemented groups. Plasma total antioxidant status (TAS) also increased linearly (p < 0.05) in V-supplemented groups. Plasma IgG levels increased linearly (p < 0.05). Plasma IGF-1 concentrations showed significant effect (p < 0.05) of V supplementation. Plasma T4 concentration increased linearly (p < 0.05). The results suggest that V supplementation may play a role in modulating the immunity and antioxidant status of growing Hariana heifers.

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The authors would like to thank the faculty of Department of Animal Nutrition and Livestock Farm Complex, DUVASU, Mathura. The authors also gratefully acknowledge Dr Atul Prakash for assistance during research work.


The fund for this study was provided by the University under Indian Council of Agricultural Research Grant, New Delhi, India.

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Correspondence to Shalini Vaswani.

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Gupta, P.K., Vaswani, S., Kumar, V. et al. Investigations on Modulating Effect of Vanadium Supplementation on Growth and Metabolism Through Improved Immune Response, Antioxidative Profile and Endocrine Variables in Hariana heifers. Biol Trace Elem Res 194, 379–389 (2020). https://doi.org/10.1007/s12011-019-01794-4

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  • Antioxidant
  • Endocrine
  • Growth
  • Hariana
  • Immunity
  • Vanadium