This investigation was conducted to determine the effects of chromium supplementation on metabolic status in diabetic patients with coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed in 64 diabetic patients with CHD between October 2017 and January 2018. Patients were randomly divided into two groups to obtain either 200 μg chromium (n = 32) or placebo (n = 32) for 12 weeks. Chromium supplementation significantly reduced body weight (− 0.9 ± 1.6 vs. + 0.1 ± 0.8 kg, P = 0.001), BMI (− 0.4 ± 0.7 vs. + 0.1 ± 0.3 kg/m2, P = 0.002), fasting glucose (β − 11.03 mg/dL; 95% CI, − 18.97, − 3.09; P = 0.007), insulin (β − 1.33 μIU/mL; 95% CI, − 1.90, − 0.76; P < 0.001), and insulin resistance (β − 0.44; 95% CI, − 0.62, − 0.25; P < 0.001) and significantly increased insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; P < 0.001) compared with the placebo. In addition, taking chromium led to a significant reduction in serum high-sensitivity C-reactive protein (hs-CRP) (β − 0.49 mg/L; 95% CI, − 0.91, − 0.06; P = 0.02) and plasma malondialdehyde (MDA) levels (β − 0.22 μmol/L; 95% CI, − 0.35, − 0.10; P = 0.001); also, a significant rise in total antioxidant capacity (TAC) (β 84.54 mmol/L; 95% CI, 31.05, 138.02; P = 0.002) was observed in comparison with placebo. Additionally, chromium administration significantly reduced diastolic blood pressure (DBP) (β − 5.01 mmHg; 95% CI, − 9.04, − 0.97; P = 0.01) compared with the placebo. Overall, the 12-week supplementation of chromium to diabetic patients with CHD had beneficial impacts on weight, BMI, glycemic control, hs-CRP, TAC, MDA, and DBP.
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angiotensin-converting enzyme inhibitors
aldosterone receptor blockers
fasting plasma glucose
homeostasis model of assessment-insulin resistance
high-sensitivity C-reactive protein
quantitative insulin sensitivity check index
very low–density lipoprotein-cholesterol
total antioxidant capacity
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The present study was supported by a grant from the Vice-chancellor for Research, KAUMS, Kashan, Iran.
The research grant was provided by Research Deputy of Kashan University of Medical Sciences (KAUMS).
The investigation was conducted based on the Declaration of Helsinki principals. The protocol of this study was approved by Research Ethics Committee, KAUMS, and Iran. Written informed consent was taken from all patients.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments.
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Farrokhian, A., Mahmoodian, M., Bahmani, F. et al. The Influences of Chromium Supplementation on Metabolic Status in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease. Biol Trace Elem Res 194, 313–320 (2020). https://doi.org/10.1007/s12011-019-01783-7
- Coronary heart disease
- Metabolic status
- Type 2 diabetes mellitus