Inhibition of Hyperuricemia and Gouty Arthritis in BALB/c Mice Using Copper Oxide Nanoparticles
- 26 Downloads
Nanoparticles are known for their unique properties and are being utilized in various disciplines of sciences. Their nanosize enables them to higher exposure and higher availability when given orally. Gout is an inflammatory disease caused by deposition of monosodium urate (MSU) crystal deposition into the joints. The objective of this study was to evaluate the effects of copper oxide nanoparticles on hyperuricemia and gouty arthritis in mice. In this research, synthesized copper oxide nanoparticles of size ranging from 30 to 50 nm were administered orally to mice having gouty arthritis and hyperuricemia. Various biochemical markers were conducted to determine the effects of copper oxide nanoparticles. It was observed that the mice treated with CuO NPs at various concentrations showed a significant (0.001) decrease in the serum uric acid levels in comparison with the negative control. Furthermore, creatinine levels were also normal in comparison with the control mice. Measurement of synovial joints also revealed that mice administered with CuO NPs had reduced inflammation of synovial joints in comparison with the negative control. From this research, it was concluded that copper oxide nanoparticles have potential in the treatment of hyperuricemia and gouty arthritis by decreasing serum uric acid and inflammation in synovial joints.
KeywordsCopper oxide Nanoparticles Gouty arthritis Hyperuricemia Uric acid Synovial joints
This manuscript is a part of the doctoral dissertation of Mubin Mustafa. The authors are thankful to International Islamic, Riphah International University, Islamabad, Pakistan, and National University of Science and Technology, Islamabad, Pakistan, for providing research facilities.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 3.Schauer C, Janko C, Munoz LE, Zhao Y, Kienhöfer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, Holmdahl R, Krenn V, Harrer T, Jeremic I, Bilyy R, Schett G, Hoffmann M, Herrmann M (2014) Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med 20(5):511–517CrossRefGoogle Scholar
- 8.Busso N, Ea H-K (2011) The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). Reumatismo 63(4):230–237Google Scholar
- 22.Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR (2014) Modern nutrition in health and disease, 11 edn. Lippincott Williams &WilkinsGoogle Scholar
- 25.Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent dietGoogle Scholar
- 26.Razavian MH, Masaimanesh M (2014) Ingestion of silver nanoparticles leads to changes in blood parameters. Nanomed J 1(5):339–345Google Scholar