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Cadmium in Seminal Plasma of Fertile and Infertile Male Dromedary Camels

  • Ahmed AliEmail author
  • Derar R. Derar
  • Essam M. Abdel-Elmoniem
  • Tariq I. Almundarij
Article
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Abstract

The objective of this study was to investigate the cadmium (Cd) profile in seminal plasma of male dromedary camel with impotentia generandi (post-coital infertility, IG group, n = 14) in comparison with known fertile males (FERT group, n = 5). Andrological examination was carried out for all animals. Semen was collected with electroejaculation and examined for volume, concentration, motility, viability, and abnormality. Seminal fluid was harvested after centrifugation and analyzed for Cd using atomic absorption spectrophotometer. Results showed that sperm concentration, motility, and viability were higher, while sperm abnormality was lower in IG group than in FERT group (P < 0.05). Cd was higher in seminal plasma of IG group than in FERT group (P = 0.04). Negative correlation was found between Cd concentration and sperm concentration (r = − 0.511, P = 0.04). There was also a tendency for negative correlation between Cd concentration and the testicular size (r = − 0.455, P = 0.05). In conclusion, Cd may be one of factors causing infertility in male dromedary camels.

Keywords

Cadmium Male dromedary camel Infertility Semen 

Notes

Funding Information

This study was financially supported by the Deanship of Research of Qassim University, Kingdome of Saudi Arabia.

Compliance with Ethical Standards

This study was approved by the Animal Care and Welfare Committee, Deanship of Scientific Research, Qassim University, Kingdom of Saudi Arabia.

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Ali A, Derar DR, Zeitoun MM, Al-Sobayil F (2018) Impotentia generandi in male dromedary camels: FSH, LH and testosterone profiles and their association with clinical findings and semen analysis data. Theriogenology 120:98–104CrossRefGoogle Scholar
  2. 2.
    Ali A, Derar R, Al-Sobayil F, Mehana S, Al-Hawas A (2014) Impotentia generandi in male dromedary camels: clinical findings, semen characteristics, and testicular histopathology. Theriogenology 82:890–896CrossRefGoogle Scholar
  3. 3.
    Pflieger-Bruss S, Schuppe HC, Schill WB (2004) The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 36:337–345CrossRefGoogle Scholar
  4. 4.
    Bonde JP (2010) Male reproductive organs are at risk from environmental hazards. Asian J Androl 12:152–156CrossRefGoogle Scholar
  5. 5.
    Pizent A, Tariba B, Živković T (2012) Reproductive toxicity of metals in men. Arh Hig Rada Toksikol 63(Suppl 1):35–46Google Scholar
  6. 6.
    Jurewicz J, Hanke W, Radwan M, Bonde JP (2009) Environmental factors and semen quality. Int J Occup Med Environ Health 22:305–329Google Scholar
  7. 7.
    Järup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182CrossRefGoogle Scholar
  8. 8.
    Tam P, Liu W (1985) Gonadal development and fertility of mice treated prenatally with cadmium during the early organogenesis stages. Teratology 32:453–462CrossRefGoogle Scholar
  9. 9.
    Thompson J, Bannigan J (2008) Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 25:304–315CrossRefGoogle Scholar
  10. 10.
    Monsefi M, Alaee S, Moradshahi A, Rohani L (2010) Cadmium induced infertility in male mice. Environ Toxicol 25:94–102Google Scholar
  11. 11.
    Guzikowski W, Szynkowska MI, Motak-Pochrzęst H, Pawlaczyk A, Sypniewski S (2015) Trace elements in seminal plasma of men from infertile couples. Arch Med Sci 11:591–598CrossRefGoogle Scholar
  12. 12.
    Sun J, Yu G, Zhang Y, Liu X, Du C, Wang L, Li Z, Wang C (2017) Heavy metal level in human semen with different fertility: a meta-analysis. Biol Trace Elem Res 176:27–36CrossRefGoogle Scholar
  13. 13.
    Sghiri A, Driancourt MA (1999) Seasonal effects on fertility and ovarian follicular growth and maturation in camels (Camelus dromedarius). Anim Reprod Sci 55:223–237CrossRefGoogle Scholar
  14. 14.
    Derar R, Hussein HA, Ali A (2012) Reference values for the genitalia of male dromedary before and after puberty using caliper and ultrasonography in subtropics. Theriogenology 77:459–465CrossRefGoogle Scholar
  15. 15.
    Wani NA, Billah M, Skidmore JA (2008) Studies on liquefaction and storage of ejaculated dromedary camel (Camelus dromedarius) semen. Anim Reprod Sci 109:309–318CrossRefGoogle Scholar
  16. 16.
    Skidmore JA, Morton KM, Billah M (2013) Artificial insemination in dromedary camels. Anim Reprod Sci 136:178–186CrossRefGoogle Scholar
  17. 17.
    Antoniou V, Zantopoulos N, Tsoukali-Papadopoulou H (1995) Selected heavy metal concentrations in goat liver and kidney. Vet Hum Toxicol 37:20–22Google Scholar
  18. 18.
    Moffat AC, Jackson JV, Moss MS, Widdop B (1986) Metals and anions. In: Clarke’s isolation and identification of drugs, 2nd edn. The Pharmaceutical Press, LondonGoogle Scholar
  19. 19.
    Fowler BA (2009) Monitoring of human populations for early markers of cadmium toxicity: a review. Toxicol Appl Pharm 238:294–300CrossRefGoogle Scholar
  20. 20.
    Morrow H (2010) Cadmium and Cadmium Alloys. Kirk-Othmer encyclopedia of chemical technology. John Wiley and Sons, pp 1–36Google Scholar
  21. 21.
    Wang YX, Wang P, Feng W, Liu C, Yang P, Chen YJ, Sun L, Sun Y, Yue J, Gu LJ, Zeng Q, Lu WQ (2017) Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity. Environ Pollut 224:224–234CrossRefGoogle Scholar
  22. 22.
    Chung NP, Cheng CY (2001) Is cadmium chloride- induced inter-Sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis? Endocrinology 142:1878–1888CrossRefGoogle Scholar
  23. 23.
    Wong C, Mruk DD, Lui W, Cheng CY (2004) Regulation of blood-testis barrier dynamics: an in vivo study. J Cell Sci 117:783–798CrossRefGoogle Scholar
  24. 24.
    Tremellen K (2008) Oxidative stress and male infertility: a clinical perspective. Hum Reprod Update 14:243–258CrossRefGoogle Scholar
  25. 25.
    Alaee S, Monsefi M (2013) Effect of cadmium on oxidative stress of testes in adult male mice. Iranian J Reprod Med 11:39–44Google Scholar
  26. 26.
    Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä SI, Åkesson A, Berglund M, Håkansson H, Halldin K (2012) Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci 127:66–75CrossRefGoogle Scholar
  27. 27.
    Noack-Füller G, De Beer C, Seibert H (1993) Cadmium, lead, selenium, and zinc in semen of occupationally unexposed men. Andrologia 25:7–12CrossRefGoogle Scholar
  28. 28.
    Xu DX, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN (2003) The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res 534(1–2):155–163CrossRefGoogle Scholar
  29. 29.
    Xu B, Chia SE, Tsakok M, Ong CN (1993) Trace elements in blood and seminal plasma and their relationship to sperm quality. Reprod Toxicol 7:613–618CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ahmed Ali
    • 1
    • 2
    Email author
  • Derar R. Derar
    • 1
    • 2
  • Essam M. Abdel-Elmoniem
    • 3
  • Tariq I. Almundarij
    • 1
  1. 1.Department of Veterinary MedicineCollege of Agriculture and Veterinary Medicine, Qassim UniversityBuraidahSaudi Arabia
  2. 2.Department of Theriogenology, Faculty of Veterinary MedicineAssiut UniversityAssiutEgypt
  3. 3.Department of SoilCollege of Agriculture and Veterinary Medicine, Buraydah, Qassim UniversityBuraidahSaudi Arabia

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