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Selenium Content and/or T-2 Toxin Contamination of Cereals, Soil, and Children’s Hair in Some Areas of Heilongjiang and Gansu Provinces, China

  • Liyan Sun
  • Silu Cui
  • Qing Deng
  • Hui Liu
  • Yanhong Cao
  • Shaoping Wang
  • Jun YuEmail author
Article
  • 19 Downloads

Abstract

It has been strongly suggested that selenium deficiency and T-2 contamination in cereals are responsible for the development of Kashin-Beck disease (KBD). In order to assess these risk factors of KBD in the internal and external environments, our team undertook a two-stage survey in some areas of Heilongjiang and Gansu Provinces, China. The selenium content in children’s hair (293), cereal (192), and soil (46) samples were determined using the 2, 3-diamino-naphthalene fluorometric assay technique. The T-2 toxin contamination level in the cereal samples (704) was assayed using an ELISA kit. There were no clinical KBD cases identified in this survey. The selenium statuses of the children in all the investigated regions during the first phase were at the medium selenium nutrition level. During the second phase, the selenium status of the children in Weiyuan County, Ning County, and Shangzhi City was at the medium selenium nutrition level, at the edge of selenium deficiency, and selenium deficient, respectively. Furthermore, the selenium contents in the cereal and soil samples were low. During the first phase, the average T-2 toxin contamination level in the family staple food samples for all the investigated regions was about 10 ng/g. However, the T-2 toxin contamination levels in eight homegrown corn samples were higher than 100 ng/g. During the second phase, all the average T-2 toxin contamination levels in the flour and corn samples from the three investigated regions were less than 10 ng/g. Risk factors that affect the prevalence of KBD still remain in the internal and external environments of some areas in Heilongjiang and Gansu Provinces.

Keywords

Selenium T-2 toxin Kashin-Beck disease Cereal Soil Hair 

Notes

References

  1. 1.
    Cao J, Li S, Shi Z, Yue Y, Sun J, Chen J, Fu Q, Hughes CE, Caterson B (2008) Articular cartilage metabolism in patients with Kashin-Beck disease: an endemic osteoarthropathy in China. Osteoarthr Cartil 16:680–688CrossRefGoogle Scholar
  2. 2.
    Wang LH, Fu Y, Shi YX, Wang WG (2011) T-2 toxin induces degenerative articular changes in rodents: link to Kachin-Beck Disease. Toxicol Pathol 39:502–507CrossRefGoogle Scholar
  3. 3.
    Sun LY, Meng FG, Li Q, Zhao ZJ, He CZ, Wang SP, Sa RL, Man WW, Wang LH (2014) Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kashin-Beck disease: an epidemiological intervention trial in the Qinghai Province. Osteoarthr Cartil 22:2033–2040CrossRefGoogle Scholar
  4. 4.
    Stone R (2009) Diseases. A medical mystery in middle China. Science 324:1378–1381CrossRefGoogle Scholar
  5. 5.
    Hinsenkamp M (2001) Kashin-Beck Disease. Int Orthop 25:133–202CrossRefGoogle Scholar
  6. 6.
    Li SY, Cao JL, Shi ZL, Chen JH, Zhang ZT, Hughes CE, Caterson B (2008) Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B 9:22–33CrossRefGoogle Scholar
  7. 7.
    Yang JB (1995) A research report on the etiology of KBD (in Chinese). Chin J Endemiol 14:201–205Google Scholar
  8. 8.
    Nascimento J, Nunes VA, Guedes RM et al (2001) T-2 toxin and disturbed endochondral bone growth in broiler chicken. Arq Bras Med Vet Zootec 53:332–340CrossRefGoogle Scholar
  9. 9.
    Ge K, Yang G (1993) The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. Am J Clin Nutr 57:259s–263sCrossRefGoogle Scholar
  10. 10.
    Zhang B, Yang L, Wang W, Li Y, Li H (2011) Environmental selenium in the Kashin-Beck disease area, Tibetan Plateau, China. Environ Geochem Health 33:495–501CrossRefGoogle Scholar
  11. 11.
    Moreno-Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Rivera MT, Boelaert M, Nève J, Perlmutter N, Vanderpas J (1998) Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112–1120CrossRefGoogle Scholar
  12. 12.
    Cai LW, Zhang YL (2005) An observation by X-ray on effect of selenium in the treatment of 40 Kashin-Beck children (in Chinese). J Comm Med 3:60–61Google Scholar
  13. 13.
    Zou K, Liu G, Wu T, du L (2009) Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthr Cartil 17:144–151CrossRefGoogle Scholar
  14. 14.
    Ministry of Health of the People’s Republic of China Document: Guidelines for health. Diagnosis of Kashin-Beck Disease, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, 2010; Register June 2, 2010 (WS/T 207–2010)Google Scholar
  15. 15.
    Kang FY, Li YJ, Wei J (2013) Analysis of selenium content in hair samples of children in Kashin-Beck disease areas in Gansu Province (in Chinese). Chin J Endemiol 35:70–72Google Scholar
  16. 16.
    Yang XD, Dai HX, Guo X (2016) Changes of selenium content in hair samples of people in Kashin-Beck disease areas two months after stopping selenium salt in Shanxi Province in 2012 (in Chinese). Chin J Endemiol 35:361–364Google Scholar
  17. 17.
    Peng A, Wang Z, Wang W et al (1991) A new hypothesis for the etiology of Kashin-Beck disease (in Chinese). J Environ Sci (China) 3:5–14Google Scholar
  18. 18.
    Ren FL, Guo X, Zhang RJ, Wang SJ, Zuo H, Zhang ZT, Geng D, Yu Y, Su M (2007) Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthr Cartil 15:1171–1177CrossRefGoogle Scholar
  19. 19.
    Miguel NA, Carmen CV (2008) Selenium in food and the human body: a review. Sci Total Environ 400:115–141CrossRefGoogle Scholar
  20. 20.
    Li SJ, Li W, Hu X et al (2008) Distribution of Kashin-Beck disease and its relation to selenium content in soil, plant, animal (human being) ecosystem in Tibet (in Chinese). Chin J Ecol 27:2167–2170Google Scholar
  21. 21.
    Wang MY (1982) Geographical distribution of selenium content of grains in China (in Chinese). Geogr Res 1:51–58Google Scholar
  22. 22.
    Shand CA, Eriksson J, Dahlin AS, Lumsdon DG (2012) Selenium concentrations in national inventory soils from Scotland and Sweden and their relationship with geochemical factors. J Geochem Explor 121:4–14CrossRefGoogle Scholar
  23. 23.
    Swaine DJ (1955) The trace element content of soils. Commonwealth Agricultural Bureaux 37–46Google Scholar
  24. 24.
    Mngadi PT, Govinden R, Odhav B (2008) Co-occurring mycotoxins in animal feeds. Afr J Biotechnol 7:2239–2243Google Scholar
  25. 25.
    Ueno Y (1984) Toxicological features of T-2 toxin and related trichothecenes. Fundam Appl Toxicol 4:S124–S132CrossRefGoogle Scholar
  26. 26.
    Scientific committee for food opinion of the scientific committee on food on Fusarium toxins. Part 5: T-2 toxin and HT-2 toxin (adapted on 30 May 2001). http://europa.eu.int/comm/food/fs/sc/scf//out88
  27. 27.
    Sun LY, Li Q, Meng FG, Fu Y, Zhao ZJ, Wang LH (2012) T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kashin-Beck disease endemic areas of Qinghai Province. Biol Trace Elem Res 150:371–375CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Liyan Sun
    • 1
    • 2
  • Silu Cui
    • 1
    • 2
  • Qing Deng
    • 1
    • 2
  • Hui Liu
    • 1
    • 2
  • Yanhong Cao
    • 1
    • 2
  • Shaoping Wang
    • 1
    • 2
  • Jun Yu
    • 1
    • 2
    Email author
  1. 1.Center for Endemic Disease Control, Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbinChina
  2. 2.Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & National Health Commission of the People’s Republic of China (23618504)HarbinChina

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