Biological Trace Element Research

, Volume 187, Issue 2, pp 464–471 | Cite as

The Resveratrol Alleviates the Hepatic Toxicity of CuSO4 in the Rat

  • Yaping Tian
  • Bing Wu
  • Xiaoping Li
  • Xuefei Jin
  • Fuqiang Zhang
  • Chunyan Jiang
  • Wenzhou Xu
  • Hang Li
  • Heyuan WangEmail author


Cu is toxic to humans and other animals. Oxidative stress is an important mechanism involved in Cu toxicity. Resveratrol (RSV) is an antioxidative compound, so could counteract Cu toxicity. The aim of this study was to determine whether RSV protects the liver from the effects of CuSO4. Forty male Sprague-Dawley rats (5 weeks old, 110–120 g) were divided into four groups (n = 10 per group), a control group and groups treated with CuSO4 at a dose of 200 mg/kg body weight (BW), RSV at a dose of 15 mg/kg BW, and CuSO4 at a dose of 200 mg/kg BW and RSV at a dose of 15 mg/kg BW. The treatments were orally administered for 30 days. The livers were removed from the rats at the end of the study, and the cytochrome P450, cytochrome b5, Cu, Fe, Zn, glutathione peroxidase, superoxide dismutase, reactive oxygen species, aspartate aminotransferase, and alanine aminotransferase concentrations in the livers were determined. CuSO4 decreased the BW, liver weight, and cytochrome P450, cytochrome b5, Fe, Zn, glutathione peroxidase, and superoxide dismutase concentrations but increased the Cu, aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species concentrations relative to the control group. RSV alleviated the toxic effects of CuSO4 on the liver, indicating that RSV attenuates CuSO4-induced liver injury by decreasing the liver transaminase concentration and oxidative stress, promoting antioxidative activity and cytochrome P450 enzymes, and maintaining balance in the trace element concentrations. The results indicate that RSV could be used to treat CuSO4 toxicity.


CuSO4 toxicity Resveratrol Trace element Oxidative stress 



Thanks for all the authors’ contribution to this manuscript.

Compliance with Ethical Standards

The experimental protocol was approved by the Ethics Committee for the Use and Care of Animals, China–Japan Union Hospital, Jilin University, China.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yaping Tian
    • 1
  • Bing Wu
    • 2
    • 3
  • Xiaoping Li
    • 4
  • Xuefei Jin
    • 5
  • Fuqiang Zhang
    • 6
  • Chunyan Jiang
    • 7
  • Wenzhou Xu
    • 8
  • Hang Li
    • 9
  • Heyuan Wang
    • 10
    • 11
    Email author
  1. 1.Department of Dermatology and Venerology of the First HospitalJilin UniversityChangchunChina
  2. 2.Department of Neurosurgery of China-Japan Union HospitalJilin UniversityChangchunChina
  3. 3.Key Laboratory of Radiobiology (Ministry of Health) of Public HealthJilin UniversityChangchunChina
  4. 4.Department of Pediatric Endocrinology of the First HospitalJilin UniversityChangchunChina
  5. 5.Department of Urology of China-Japan Union HospitalJilin UniversityChangchunChina
  6. 6.Science and Research Center of China-Japan Union HospitalJilin UniversityChangchunChina
  7. 7.Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjinChina
  8. 8.Department of Stomatology, Stomatological HospitalJilin UniversityChangchunChina
  9. 9.Department of Hepatobiliary and pancreatic surgery, China-Japan Union HospitalJilin UniversityChangchunChina
  10. 10.Department of Endocrinology and Metabolism of the First HospitalJilin UniversityChangchunChina
  11. 11.Department of Immunology in College of Basic Medical SciencesJilin UniversityChangchunChina

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