Serum Concentrations of 15 Elements Among Helicobacter Pylori-Infected Residents from Lujiang County with High Gastric Cancer Risk in Eastern China
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Helicobacter pylori (H. pylori) infection can interfere with the absorption of most elements, and the variations of some element levels are related to the incidence of gastric cancer. However, there have been conflicting results concerning the influence of H. pylori infection on serum element levels. The present study aimed to compare the serum element concentrations of H. pylori-infected local residents with uninfected residents from Lujiang County with high gastric cancer risk in Eastern China. We used data and serum samples from the H. pylori screening-survey program which was a cross-sectional study. We took 155 samples randomly from the screening survey, identified 74 H. pylori-positive residents and 81 H. pylori-negative residents by a serological test. The serum concentrations of 15 elements (calcium, magnesium, iron, zinc, selenium, copper, molybdenum, chromium, cobalt, nickel, lead, cadmium, mercury, arsenic, and aluminum) were determined using inductively coupled plasma mass spectrometry. Serum cobalt was found at higher levels in the H. pylori-infected residents than the H. pylori-uninfected residents (0.246 vs 0.205 μg/L, P = 0.022), but no statistically significant differences in the serum levels of other elements were found. This is the first study to report the serum concentrations of 15 elements and their relationships with the infection status of H. pylori among local residents from Lujiang County with high gastric cancer risk. Although the International Agency for Research on Cancer has classified cobalt and other soluble cobalt salts as possibly carcinogenic to human beings, our results may provide a clue to the relationships between cobalt, H. pylori, and gastric cancer.
KeywordsGastric cancer Helicobacter pylori Elements Cobalt
This study was funded by the National Natural Science Foundation of China (No. 81502806) and Grant for Scientific Research of BSKY from Anhui Medical University (No. XJ201523).
Compliance with Ethical Standards
This study received ethical approval from the Ethics Institutional Review Board from the Anhui Medical University. Written informed consents were obtained from all participants before taking part in the study.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 5.Hongyu C, Shuang J, Haiting C, Ran C, Xiaowen D, Guanglie H, Fen H (2015) Analysis of cancer prevalence in Lujiang county of Anhui Province during 2010–2012. Chin J Prevent Control Chronic Dis 23(2):113–115Google Scholar
- 13.Abbasciano V, Sartori S, Trevisani L, Girometti R, Ranzini M, Nielsen I, Mazzotta D, Vecchiatti G, Bononi A, Guglielmini C (2003) Comparison of magnesium concentration in serum, erythrocytes and gastric tissue in two groups of patients affected by chronic gastritis, Helicobacter pylori negative and positive. Magnes Res 16(4):281–286PubMedGoogle Scholar
- 14.Janjetic MA, Goldman CG, Balcarce NE, Rua EC, Gonzalez AB, Fuda JA, Meseri EI, Torti HE, Barrado J, Zubillaga MB, Lopez LB, Boccio JR (2010) Iron, zinc, and copper nutritional status in children infected with Helicobacter pylori. J Pediatr Gastroenterol Nutr 51(1):85–89. https://doi.org/10.1097/MPG.0b013e3181c2c2cd CrossRefPubMedGoogle Scholar
- 18.Zhao Q, Wang Y, Cao Y, Chen A, Ren M, Ge Y, Yu Z, Wan S, Hu A, Bo Q, Ruan L, Chen H, Qin S, Chen W, Hu C, Tao F, Xu D, Xu J, Wen L, Li L (2014) Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Sci Total Environ 470-471:340–347. https://doi.org/10.1016/j.scitotenv.2013.09.086 CrossRefPubMedGoogle Scholar
- 20.Yuehong W, Zhu G, Nong X, Yijia W, Hua L (2005) A case-control study on the relationship between self-made foods and gastric cancer in rural areas. Ji bing kong zhi za zhi [Chin J Dis Control Prev] 9(5):387–389Google Scholar
- 21.Matsuda T, Tao H, Goto M, Yamada H, Suzuki M, Wu Y, Xiao N, He Q, Guo W, Cai Z, Kurabe N, Ishino K, Matsushima Y, Shinmura K, Konno H, Maekawa M, Wang Y, Sugimura H (2013) Lipid peroxidation-induced DNA adducts in human gastric mucosa. Carcinogenesis 34(1):121–127. https://doi.org/10.1093/carcin/bgs327 CrossRefPubMedGoogle Scholar
- 23.Qiao YL, Dawsey SM, Kamangar F, Fan JH, Abnet CC, Sun XD, Johnson LL, Gail MH, Dong ZW, Yu B, Mark SD, Taylor PR (2009) Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst 101(7):507–518. https://doi.org/10.1093/jnci/djp037 CrossRefPubMedPubMedCentralGoogle Scholar
- 29.Cai L, Chen T, Yang J, Zhou K, Yan X, Chen W, Sun L, Li L, Qin S, Wang P, Yang P, Cui D, Burmeister M, He L, Jia W, Wan C (2015) Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population. Sci Rep 5:15013. https://doi.org/10.1038/srep15013 CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Garcia-Esquinas E, Pollan M, Umans JG, Francesconi KA, Goessler W, Guallar E, Howard B, Farley J, Best LG, Navas-Acien A (2013) Arsenic exposure and cancer mortality in a US-based prospective cohort: the strong heart study. Cancer Epidemiol Biomark Prev 22(11):1944–1953. https://doi.org/10.1158/1055-9965.EPI-13-0234-T CrossRefGoogle Scholar
- 32.Garcia-Esquinas E, Pollan M, Tellez-Plaza M, Francesconi KA, Goessler W, Guallar E, Umans JG, Yeh J, Best LG, Navas-Acien A (2014) Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study. Environ Health Perspect 122(4):363–370. https://doi.org/10.1289/ehp.1306587 CrossRefPubMedPubMedCentralGoogle Scholar
- 37.Liu LZ, Ding M, Zheng JZ, Zhu Y, Fenderson BA, Li B, Yu JJ, Jiang BH (2015) Tungsten carbide-cobalt nanoparticles induce reactive oxygen species, AKT, ERK, AP-1, NF-kappaB, VEGF, and angiogenesis. Biol Trace Elem Res 166(1):57–65. https://doi.org/10.1007/s12011-015-0331-6 CrossRefPubMedGoogle Scholar
- 40.Choi R, Kim HT, Lim Y, Kim MJ, Kwon OJ, Jeon K, Park HY, Jeong BH, Koh WJ, Lee SY (2015) Serum concentrations of trace elements in patients with tuberculosis and its association with treatment outcome. Nutrients 7(7):5969–5981. https://doi.org/10.3390/nu7075263 CrossRefPubMedPubMedCentralGoogle Scholar
- 42.Mohmand J, Eqani SA, Fasola M, Alamdar A, Mustafa I, Ali N, Liu L, Peng S, Shen H (2015) Human exposure to toxic metals via contaminated dust: bio-accumulation trends and their potential risk estimation. Chemosphere 132:142–151. https://doi.org/10.1016/j.chemosphere.2015.03.004 CrossRefPubMedGoogle Scholar