Biological Trace Element Research

, Volume 186, Issue 1, pp 1–8 | Cite as

An Advanced Formulation of a Magnesium Dietary Supplement Adapted for a Long-Term Use Supplementation Improves Magnesium Bioavailability: In Vitro and Clinical Comparative Studies

  • Christian Dualé
  • Jean-Michel Cardot
  • Fabienne Joanny
  • Anna Trzeciakiewicz
  • Elodie Martin
  • Gisèle Pickering
  • Claude DubrayEmail author


While general recommendations are for 300-mg magnesium intake a day, an advanced low-dose formulation of magnesium chloride, ChronoMag®, was designed to provide 100 mg of magnesium element, thus decreasing the risk of gastrointestinal side effects and allowing long-term supplementation in health conditions related to low magnesium levels. The present study aimed to compare magnesium release profile and bioavailability between this patented low-dose continuous-release magnesium chloride tablet (100 mg magnesium element) and a reference tablet at the usually prescribed dose (300 mg magnesium element). Magnesium release profile was determined by dissolving the tablets in solutions simulating the gastrointestinal tract environment. A randomized double-blind crossover controlled trial of ChronoMag® versus reference tablet (3 × 100 mg magnesium element tablets) in 12 normo-magnesemic healthy volunteers was conducted to evaluate the bioavailability of the patented magnesium chloride tablets (two 50 mg magnesium tablets, once-a-day intake). While the reference tablet released 100% of its magnesium within 1 h of dissolution, release from the magnesium chloride formulation was continuous for 6 h. Cumulative urinary magnesium levels compared to those with the reference tablet were 76% (0–5 h), 89% (0–10 h), and 87% (0–24 h). Elimination after 24 h was fairly similar with both supplements. Our results suggest that the new magnesium chloride formulation, providing continuous low-dose magnesium release throughout the gastrointestinal tract, improves absorption and bioavailability. This formulation conforms to the physiological mechanism of magnesium absorption throughout the digestive tract, allowing high absorption, and may improve gastrointestinal tolerance in long-term use.


Magnesium element Magnesium chloride Low dose Continuous release Improved absorption Long-term supplementation 



We would like to thank Pr. A. Berthelot, Dr. B. Shroot, Y. Marchenay, and Dr. Y. Juillet for their intellectual contribution to the study.

Funding Information

This study was sponsored by FJ LIFE SCIENCES.

Compliance with Ethical Standards

The randomized, double-blind, crossover, controlled trial in healthy volunteers (registration number with the French health products safety agency, ANSM: 2013-001631-43; trial number: NCT01935570) was conducted in the Clinical Pharmacology Center of the University Hospital of Clermont-Ferrand (France), in compliance with the principles of the Declaration of Helsinki and following Good Clinical Practices. Review board approval (CPP Sud-Est VI, Clermont-Ferrand, France) was obtained before the start of the study. Subjects were enrolled after giving written informed consent and fulfilling inclusion and exclusion criteria. Dr. Joanny declares she is the Founder and CEO of FJ LIFE SCIENCES.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Christian Dualé
    • 1
    • 2
  • Jean-Michel Cardot
    • 2
  • Fabienne Joanny
    • 3
  • Anna Trzeciakiewicz
    • 3
  • Elodie Martin
    • 3
  • Gisèle Pickering
    • 1
    • 2
  • Claude Dubray
    • 1
    • 2
    Email author
  1. 1.Pharmacologie Fondamentale et Clinique de la Douleur, Neuro-DolUniversité Clermont AuvergneClermont-FerrandFrance
  2. 2.Centre de Pharmacologie Clinique / Centre d’Investigation Clinique Inserm 1405CHU Clermont-FerrandClermont-Ferrand Cedex 1France
  3. 3.FJ RECHERCHE & DEVELOPPEMENT, Research OrganizationParisFrance

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