Biological Trace Element Research

, Volume 185, Issue 1, pp 244–251 | Cite as

Antioxidant and Cytoprotective Activity of Oxydiacetate Complexes of Cobalt(II) and Nickel(II) with 1,10-Phenantroline and 2,2′-Bipyridine

  • Agnieszka Piotrowska-Kirschling
  • Joanna Drzeżdżon
  • Anna Kloska
  • Dariusz Wyrzykowski
  • Lech Chmurzyński
  • Dagmara JacewiczEmail author


The antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2′-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.


Cobalt(II) and nickel(II) complexes Cytoprotective activity Fibroblasts Oxydiacetate ion Oxidative stress 


Funding information

This work was supported by National Science Centre, Poland, under Grant number 2015/19/N/ST5/00276.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Agnieszka Piotrowska-Kirschling
    • 1
  • Joanna Drzeżdżon
    • 1
  • Anna Kloska
    • 2
  • Dariusz Wyrzykowski
    • 1
  • Lech Chmurzyński
    • 1
  • Dagmara Jacewicz
    • 1
    Email author
  1. 1.Faculty of ChemistryUniversity of GdańskGdańskPoland
  2. 2.Faculty of BiologyUniversity of GdańskGdańskPoland

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