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Biological Trace Element Research

, Volume 185, Issue 1, pp 106–115 | Cite as

Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium

  • Nasim Babaknejad
  • Somaye Bahrami
  • Ali Asghar Moshtaghie
  • Hashem Nayeri
  • Parvin Rajabi
  • Farhad Golshan Iranpour
Article
  • 287 Downloads

Abstract

Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rats each. The Cd group was treated with 1 mg Cd/kg and the control group received 0.5 cm3 normal saline. The other eight groups received Zn (0.5 and 1.5 mg/kg) and Mg (0.5 and 1.5 mg/kg) either alone or in combination with 1 mg Cd/kg through IP injection for 3 weeks. Testis malondialdehyde (MDA), sperm parameters, and testis histopathology were investigated. Cd reduced sperm parameters and increased testis MDA. Moreover, Cd exposure caused a significant histological damage in testis of male rats. However, Zn or Mg treatment prevented and reversed Cd toxic alterations in testis. These findings suggest that co-administration of Zn or Mg could improve cadmium testicular toxicity in male Wistar rats.

Keywords

Cadmium Testicular toxicity Zinc Magnesium 

Notes

Authors’ Contributions

All authors participated in the writing of this paper.

Compliance with Ethical Standards

The study was approved by Isfahan University of Medical Science Experimental Animals Local Ethics Committee

Conflict of Interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017
Corrected publication December/2017

Authors and Affiliations

  • Nasim Babaknejad
    • 1
    • 2
  • Somaye Bahrami
    • 1
  • Ali Asghar Moshtaghie
    • 1
  • Hashem Nayeri
    • 1
  • Parvin Rajabi
    • 3
  • Farhad Golshan Iranpour
    • 4
  1. 1.Department of Biochemistry, Falavarjan BranchIslamic Azad UniversityIsfahanIran
  2. 2.Department of Biology, Faculty of Basic SciencesShahrekord UniversityShahrekordIran
  3. 3.Department of PathologyIsfahan University of Medical SciencesIsfahanIran
  4. 4.Department of Anatomy SciencesIsfahan University of Medical SciensesIsfahanIran

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