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Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency

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Abstract

This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.

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Authors and Affiliations

  1. Health Service Vocational School of Higher Education, University of Giresun, Giresun, Turkey

    Sevim Çiftçi Yegin

  2. Faculty of Veterinary Science, Department of Biochemistry, University of Yüzüncü Yıl, Van, Turkey

    Semiha Dede

  3. Faculty of Veterinary Science, Department of Physiology, University of Yüzüncü Yıl, Van, Turkey

    Leyla Mis

  4. Fethiye School of Health, Department of Nutrition and Dietetics, University of Muğla Sıtkı Koçman, Muğla, Turkey

    Fatmagül Yur

Authors
  1. Sevim Çiftçi Yegin
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  2. Semiha Dede
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  3. Leyla Mis
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  4. Fatmagül Yur
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Correspondence to Fatmagül Yur.

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The authors declare no conflict of interest. All authors have read and approved the final manuscript.

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Yegin, S.Ç., Dede, S., Mis, L. et al. Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency. Biol Trace Elem Res 176, 338–341 (2017). https://doi.org/10.1007/s12011-016-0826-9

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  • DOI: https://doi.org/10.1007/s12011-016-0826-9

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