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Radiolabeling of Biogenic Magnetic Nanoparticles with Rhenium-188 as a Novel Agent for Targeted Radiotherapy

  • Somayeh Akbari-Karadeh
  • Seyed Mahmoud Reza AghamiriEmail author
  • Parisa Tajer-Mohammad-GhazviniEmail author
  • Saeid Ghorbanzadeh-Mashkani
Article
  • 9 Downloads

Abstract

Use of nanoparticles as carriers of anticancer drugs is a suitable way for targeted drug delivery and reduction of the side effects. This research focuses on a novel drug carrier for therapeutic goals by the bacterial magnetic nanoparticles (magnetosomes). The unique characteristics of magnetosomes make them ideal nanobiotechnological materials. In this study, magnetic nanoparticles of Alphaproteobacterium MTB-KTN90 were labeled with the radioisotope rhenium-188 and optimized the factors affecting the labeling efficiency. The results showed that the labeling efficiency of magnetosomes with rhenium-188 was more than 96%. The optimum concentration of bacterial nanoparticles was 133 mg/ml and the best time for maximum efficiency labeling was 60 min. The labeling stability showed that the 188Re-nanoparticle complexes have good stability in 29 h. The results of magnetic nanoparticles bacterial cytotoxicity on cancer cells AsPC1 did not show significant toxicity to concentration of 100 μg/μl. Finally, the biogenic magnetic nanoparticles labeled with rhenium-188 can be introduced as a valuable candidate for the targeted therapy of tumor with reducing radiation to surrounding healthy tissues.

Keywords

Drug delivery Magnetosomes Magnetotactic bacteria Nanobiotechnology Targeted therapy 

Notes

Acknowledgments

This manuscript was a part of the MSc. thesis by S. Akbari-Karadeh, under the supervision of Dr. S.M.R. Aghamiri and Dr. P. Tajer-Mohammad-Ghazvini; and advisory of S. Ghorbanzadeh-Mashkani. The authors would like to thank Department of Medical Radiation Engineering, Shahid Beheshti University and also Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran for the supports through this study. The authors are grateful to Dr. Reza Dabbagh and Dr. Behrooz Alirezapour for their valuable contributions to this project.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Somayeh Akbari-Karadeh
    • 1
  • Seyed Mahmoud Reza Aghamiri
    • 1
    Email author
  • Parisa Tajer-Mohammad-Ghazvini
    • 2
    Email author
  • Saeid Ghorbanzadeh-Mashkani
    • 3
  1. 1.Department of Medical Radiation EngineeringShahid Beheshti UniversityTehranIran
  2. 2.Materials and Nuclear Fuel Research SchoolNuclear Science and Technology Research InstituteTehranIran
  3. 3.Nuclear Science and Technology Research InstituteTehranIran

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