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Applied Biochemistry and Biotechnology

, Volume 186, Issue 1, pp 1–11 | Cite as

Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer

  • Sreedev Puthur
  • A. N Anoopkumar
  • Sharrel Rebello
  • Embalil Mathachan Aneesh
Article

Abstract

Mosquito control with naturally derived herbal insecticides has gained much momentum, with the increased insecticide resistance of vectors and the multiple infectious diseases spread by them. Yet, recent studies also suggest that mosquitoes could probably transmit some cancerous cells or cancer-causing viruses from one individual to another between their blood meals. The current research thus focused on the screening and characterization of novel plants with both mosquitocidal and anticancerous properties. Accordingly, different solvent extracts of Hypericum japonicum, a key plant in Chinese medicine, were screened for its larvicidal efficacy using the fourth instar larvae of Aedes aegypti (major vector of Dengue and chikungunya). Methanolic extracts of the plant showed effective larvicidal property with LC50 7.37 ppm and LC9011.59 ppm values. The anticancerous property of the plant extract was also evaluated by in vitro cytotoxicity assay against Daltons Lymphoma Ascites (DLA) cells. The results indicated that H. japonicum plant extracts at very low concentrations of LC500.95 ppm and LC901.85 ppm were potent cytotoxic agents. To the best of our knowledge, this is the first and the foremost report of Hypericum japonicum as a potent mosquitocidal and anticancerous agent. Identification and characterization of such plant-derived bioactive plants thus could serve as a double-headed sword against the spread of infectious diseases and cancer.

Keywords

Aedes aegypti Hypericum japonicum Larval bioassay Cytotoxicity DLA cells 

Abbreviation

A. aegypti

Aedes aegypti

LCL

Lower confidence limit

UCL

Upper confidence limit

LD

Lethal Dose

DLA

Daltons Lymphoma Ascites cells

Notes

Acknowledgements

The authors are thankful to the Principal of St. Joseph’s College for the laboratory facilities provided. We acknowledge UGC, Govt. of India, and Kerala State Council for Science Technology and Environment (KSCSTE) for funds under Major Research Project (No. 27/SRSLS/2013/CSTE).

Compliance with Ethical Standards

Conflict of Interests

The authors declare that they have no conflict of interests.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sreedev Puthur
    • 1
  • A. N Anoopkumar
    • 1
  • Sharrel Rebello
    • 1
  • Embalil Mathachan Aneesh
    • 2
  1. 1.Communicable Disease Research LaboratorySt. Joseph’s College, IrinjalakudaThrissurIndia
  2. 2.Department of ZoologySt.Joseph’s College, IrinjalakudaThrissurIndia

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