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Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities

  • Mengke Peng
  • Xiaodan Zhang
  • Xiao Xiao
  • Mengjin Dong
  • Guowei Zhao
  • Peng Liu
  • Yashao ChenEmail author
  • Changhao WangEmail author
Article
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Abstract

Magnesium alloy (MgA) was widely used in biomedical field owing to its good biocompatibility and degradability. The surface of MgA was usually modified to improve its corrosion resistance, biocompatibility, and biological properties. Herein, we employed a layer-by-layer assembly technique to assemble both polyanionic and polycationic electrolytes onto the microarc oxidation-treated MgA surface to yield MgA-MgO-PEI-[Ge(HANPs)/Lzm]50, where the gelatin-conjugated hydroxyapatite nanoparticles [Ge(HANPs)] are the polyanionic electrolyte, lysozyme (Lzm) is the polycationic electrolyte, and polyethyleneimine (PEI) is the transition layer. The morphology and chemical composition of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 were characterized by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy, indicating that [Ge(HANPs)/Lzm]50 were successfully fabricated on the surface of MgA-MgO. The surface of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 exhibited good hydrophilicity as evidenced by the low water contact angle of 24.5°. Excellent corrosion resistance of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 was obtained since it can decrease about four orders of magnitude of corrosive current (Icorr) compared to pristine MgA. The biological assay for MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 showed good antiplatelet adhesion and excellent antibacterial activities against both E. coli and S. aureus.

Graphical abstract

Keywords

Magnesium alloy Polyelectrolytes LbL assembly Antiplatelet adhesion Antibacterial activities 

Notes

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos. 21773149, 21273142, 21703132), State Key Project of Research and Development (No. 2016YFC1100300), and Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R33).

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Copyright information

© American Coatings Association 2019

Authors and Affiliations

  • Mengke Peng
    • 1
  • Xiaodan Zhang
    • 1
  • Xiao Xiao
    • 1
  • Mengjin Dong
    • 1
  • Guowei Zhao
    • 1
  • Peng Liu
    • 2
  • Yashao Chen
    • 1
    Email author
  • Changhao Wang
    • 1
    Email author
  1. 1.Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anChina
  2. 2.Key Laboratory of Biorheological Science and Technology (Ministry of Education), College of BioengineeringChongqing UniversityChongqingChina

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