Role of PFO Closure in Ischemic Stroke Prevention

  • Nicholas D. OsteraasEmail author
  • Alejandro Vargas
  • Laurel Cherian
  • Sarah Song
Cerebrovascular Disease and Stroke (S Silverman, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cerebrovascular Disease and Stroke


Purpose of review

To highlight recent advancements in the management of acute ischemic stroke patients with patent foramen ovale (PFO).

Recent findings

One significant recent development was publication of long-term follow-up data from the RESPECT trial demonstrating evidence in favor of PFO closure over medical management. This data subsequently led to FDA approval for AMPLATZER™ septal occluder in the treatment of patients aged 18 to 60 years with both PFO and no other determined etiology for ischemic stroke, otherwise referred to as embolic stroke of undetermined source. Several subsequent closure trial results have recently been published, which also demonstrated benefit of PFO closure over medical management for ischemic stroke risk reduction in select patients. Based on the results of the more recently published REDUCE trial, the FDA granted approval for the GORE™ septal occluder.


There is current, well-established evidence that PFO closure for secondary stroke prevention is effective in select cases.


PFO closure Ischemic stroke Secondary prevention 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Nicholas D. Osteraas
    • 1
    Email author
  • Alejandro Vargas
    • 1
  • Laurel Cherian
    • 1
  • Sarah Song
    • 1
  1. 1.Rush University Medical CenterChicagoUSA

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