Pulmonary Hypertension in Patients Eligible for Transcatheter Mitral Valve Repair: Prognostic Impact and Clinical Implications

  • Evin YucelEmail author
  • Rasha Al-Bawardy
  • Philippe B. Bertrand
Valvular Heart Disease (J Dal-Bianco, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Valvular Heart Disease


Purpose of review

Transcatheter edge-to-edge mitral valve repair (TMVr) has been increasingly used in the treatment of patients with severe symptomatic mitral regurgitation who are at high or prohibitive risk for surgical intervention. Pre-existing pulmonary hypertension is known to pertain worse prognosis for patients who are undergoing surgical intervention. The aim of this review is to discuss the current literature on the effects of pulmonary hypertension on the transcatheter edge-to-edge mitral valve repair outcomes.

Recent findings

Large registry data in patients undergoing TMVr for treatment of severe mitral regurgitation reveal a significant negative impact of baseline pulmonary hypertension on post-procedural outcomes.


Pulmonary hypertension is associated with increased mortality and heart failure readmissions in patients undergoing TMVr using MitraClip. Further prospective studies are needed to determine whether earlier intervention will improve clinical outcomes.


Mitral regurgitation Transcutaneous mitral valve repair MitraClip Transcatheter mitral valve repair Pulmonary hypertension 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Evin Yucel
    • 1
    Email author
  • Rasha Al-Bawardy
    • 2
  • Philippe B. Bertrand
    • 1
  1. 1.Cardiac Ultrasound Laboratory, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  2. 2.Cardiac Catheterization Laboratory, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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