First- and Second-Generation Temporary Implantable Nitinol Devices As Minimally Invasive Treatments for BPH-Related LUTS: Systematic Review of the Literature
In the last decade, there has been a growing interest in minimally invasive treatment for benign prostatic hyperplasia (BPH) associated with lower urinary tract symptoms (LUTS). In this field, one of the options currently available is the temporary implantable nitinol device (iTIND) (Medi-Tate®; Medi-Tate Ltd., Or Akiva, Israel).
Purpose of the Work
To review the recent data available in the literature regarding the role of the first-generation (TIND) and second-generation (iTIND) devices for the management of BPH with LUTS, especially focusing on follow-up of functional outcomes.
PubMed, Embase, and the Cochrane Central Register of Controlled Trials were screened for clinical trials on this topic.
Literature evidences regarding implantation of TIND and iTIND for PBH with LUTS are limited. There are only three studies available, one with a medium-term follow-up. The results of these studies suggested that both the TIND and iTIND implantations are safe, effective, and well-tolerated procedures, allowing spare ejaculation in sexually active patients.
Current evidences emphasize that the temporary implantable nitinol devices are promising alternatives to the standard minimally invasive surgical options for BPH-related LUTS. Further studies are needed to confirm the effectiveness over a long-term follow-up.
KeywordsBPH LUTS iTIND Minimally invasive techniques Nitinol Urethral implantable device
Compliance with Ethical Standards
Conflict of Interest
Daniele Amparore, Sabrina De Cillis, Gabriele Volpi, Enrico Checcucci, Matteo Manfredi, Ivano Morra, Michele Di Dio, Cristian Fiori, and Francesco Porpiglia each declares no potential conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
- 3.•• Dahm P, Brasure M, MacDonald R, Olson CM, Nelson VA, Fink HA, et al. Comparative effectiveness of newer medications for lower urinary tract symptoms attributed to benign prostatic hyperplasia: a systematic review and meta-analysis. Eur Urol. 2017;71(4):570–81. A complete resign of the available medical treatment of BPH. CrossRefGoogle Scholar
- 7.DE Nunzio C, Lombardo R, Nacchia A, Deroma M, Alkhatatbeh H, Brassetti A, et al. Young academic urologist benign prostatic obstruction nomogram predicts clinical outcome in patients treated with transurethral resection of prostate: an Italian cohort study. Minerva Urol Nefrol. 2017. https://doi.org/10.23736/S0393-2249.17.03008-9.
- 16.•• Porpiglia F, Fiori C, Bertolo R, Garrou D, Cattaneo G, Amparore D. Temporary implantable nitinol device (TIND): a novel, minimally invasive treatment for relief of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH): feasibility, safety and functional results at 1 year of follow-up. BJU Int. 2015;116(2):278–87. Literature showing clinical results of the temporary implantable nitinol device. CrossRefGoogle Scholar
- 17.•• Porpiglia F, Fiori C, Amparore D, Kadner G, Manit A, Valerio M, et al. Second-generation of temporary implantable nitinol device for the relief of lower urinary tract symptoms due to benign prostatic hyperplasia: results of a prospective, multicentre study at 1 year of follow-up. BJU Int. 2018;123:1061–9. https://doi.org/10.1111/bju.14608. Literature showing clinical results of the temporary implantable nitinol device. CrossRefPubMedGoogle Scholar
- 21.•• Porpiglia F, Fiori C, Bertolo R, Giordano A, Checcucci E, Garrou D, et al. Three-year follow-up of temporary implantable nitinol device (TIND®) implantation for the treatment of benign prostatic obstruction. BJU Int. 2018;122:106–12. https://doi.org/10.1111/bju.14141. Literature showing clinical results of the temporary implantable nitinol device. CrossRefPubMedGoogle Scholar