Outcomes of Surgery in Peyronie’s Disease Following Intralesional Collagenase Clostridium Histolyticum Injections
- 5 Downloads
Purpose of Review
To explore the potential hurdles surgeons may encounter when preforming surgical correction of penile curvature in patients with Peyronie’s Disease following intralesional collagenase clostridium histolyticum injections.
Although limited data exists, retrospective analysis of surgeon experiences in surgical treatment of refractory penile curvature in patients with Peyronie’s disease appears to not result in more post-operative complications and may only slightly increase intra-operative difficulty.
As the use of intralesional collagenase clostridium histolyticum continues to increase and patients who demonstrate persistent curvature despite treatment seek further management, the role of investigating the feasibility of surgery demonstrates significant importance. Although limited data exists, it appears that surgery following intralesional collagenase clostridium histolyticum is safe without added post-operative complications. At the present time, however, further data on intra-operative findings and post-operative outcomes remain necessary, and as the use of this intralesional therapy continues to rise, further information should become readily available.
KeywordsPeyronie’s disease Collagenase clostridium histolyticum Reconstructive surgery Refractory curvature Surgical outcome Sexual medicine
The authors and editors would like to thank Dr. Bahaa Malaeb, University of Michigan, for providing the review of their manuscript.
Compliance with Ethical Standards
Conflict of Interest
Mahdi Bazzi and Marcus L. Jamil each declare no potential conflicts of interest.
Ali A. Dabaja is a section editor for Current Urology Reports.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
- 14.Valenzuela R, et al. The use of penile traction therapy in the management of Peyronie’s disease: current evidence and future prospects. Therapeutic advances in urology, vol. 11; 2019. p. 1756287219838139.Google Scholar
- 21.Kayes O, Khadr R. Recent advances in managing Peyronie’s disease. F1000Res. 2016;5:F1000 Faculty Rev-2372.Google Scholar
- 24.• DeLay K, et al. Successful treatment of residual curvature in Peyronie disease in men previously treated with intralesional collagenase clostridium histolyticum. Urology. 2017;110:110–3 This retrospective review by DeLay et al. outlines the foundation for the fundamental question in our review; it assesses the safety and outcomes of surgical correction of penile curvature following CCH injections. PubMedGoogle Scholar
- 30.Carson Iii CC, et al. Analysis of the clinical safety of intralesional injection of collagenase clostridium histolyticum (CCH) for adults with Peyronie’s disease (PD). BJU Int. 2015;116(5):815–22.Google Scholar
- 33.Gelbard M, Goldstein I, Hellstrom WJG, McMahon CG, Smith T, Tursi J, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190(1):199–207.PubMedGoogle Scholar
- 36.Cayan S et al. Comparison of patient’s satisfaction and long-term results of two penile plication techniques: lessons learned from 387 patients with penile curvature. Urology. 2019.Google Scholar
- 37.• Wayne GF, Cordon BH. Contemporary surgical and non-surgical management of Peyronie’s disease. Transl Androl Urol. 2018;7(4):603–17 This review article by Wayne et al. outlines many of the commonly performed medical and surgical interventions available to patients afflicted by Peyronie’s disease. PubMedPubMedCentralGoogle Scholar