Current Urology Reports

, 20:42 | Cite as

Outcomes of Surgery in Peyronie’s Disease Following Intralesional Collagenase Clostridium Histolyticum Injections

  • Mahdi Bazzi
  • Marcus L. Jamil
  • Ali A. DabajaEmail author
Men's Health (A Dabaja, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Men’s Health


Purpose of Review

To explore the potential hurdles surgeons may encounter when preforming surgical correction of penile curvature in patients with Peyronie’s Disease following intralesional collagenase clostridium histolyticum injections.

Recent Findings

Although limited data exists, retrospective analysis of surgeon experiences in surgical treatment of refractory penile curvature in patients with Peyronie’s disease appears to not result in more post-operative complications and may only slightly increase intra-operative difficulty.


As the use of intralesional collagenase clostridium histolyticum continues to increase and patients who demonstrate persistent curvature despite treatment seek further management, the role of investigating the feasibility of surgery demonstrates significant importance. Although limited data exists, it appears that surgery following intralesional collagenase clostridium histolyticum is safe without added post-operative complications. At the present time, however, further data on intra-operative findings and post-operative outcomes remain necessary, and as the use of this intralesional therapy continues to rise, further information should become readily available.


Peyronie’s disease Collagenase clostridium histolyticum Reconstructive surgery Refractory curvature Surgical outcome Sexual medicine 



The authors and editors would like to thank Dr. Bahaa Malaeb, University of Michigan, for providing the review of their manuscript.

Compliance with Ethical Standards

Conflict of Interest

Mahdi Bazzi and Marcus L. Jamil each declare no potential conflicts of interest.

Ali A. Dabaja is a section editor for Current Urology Reports.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Henry Ford Health SystemVattikuti Urology InstituteDetroitUSA

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