BPH: Why Do Patients Fail Medical Therapy?

  • Zeynep G. Gul
  • Steven A. KaplanEmail author
Benign Prostatic Hyperplasia (K McVary, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Benign Prostatic Hyperplasia


Purpose of Review

In this article, we review why patients may fail medical therapy for benign prostatic hyperplasia (BPH) and by doing so, gain a better understanding of the disease process and how to optimize the care of these patients.

Recent Findings

A growing body of literature has attempted to better characterize the various mechanisms by which patients develop BPH as well as identify predictors of disease progression and treatment failure.


BPH is a heterogenous disease process. A more personalized approach to treatment, including patient selection for medical or surgical management, would allow us to optimize patient care.


Benign prostatic hyperplasia Medical therapy Alpha-blockers 5alpha-reductase inhibitors Predictors of treatment failure Clinical trial results 


Compliance with Ethical Standards

Conflict of Interest

Zeynep G. Gul and Steven A. Kaplan each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of UrologyIcahn School of medicine at Mount SinaiNew YorkUSA

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