Use of Mannitol for Ischemia Reperfusion Injury in Kidney Transplant and Partial Nephrectomies—Review of Literature
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Purpose of Review
Few procedures involve the ischemia-reperfusion injury to organs purposely. Two clear examples in urologic surgery consist on kidney transplantation and partial nephrectomies.
Mannitol is an osmotic diuretic that is commonly used in partial nephrectomies and kidney transplantation to increase renal blood flow and decrease warm-ischemia-related renal injury to preserve estimated glomerular filtration rate (eGFR).
We review the current evidence for the use of mannitol and its effects on these procedures.
KeywordsRenal transplant Mannitol Ischemia-reperfusion injury Partial nephrectomy
Compliance with Ethical Standards
Conflict of Interest
Jose Alejandro Lugo-Baruqui, Rajinikanth Ayyathurai, Adavan Sriram, and Kothai Divya Pragatheeshwar each declare no potential conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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